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Metabolic Brain Disease

, Volume 32, Issue 5, pp 1675–1684 | Cite as

Assessment of gender and age effects on serum and hair trace element levels in children with autism spectrum disorder

  • Anatoly V. Skalny
  • Natalia V. Simashkova
  • Anastasia A. Skalnaya
  • Tatiana P. Klyushnik
  • Geir Bjørklund
  • Margarita G. Skalnaya
  • Alexey A. TinkovEmail author
Original Article

Abstract

The primary objective of the present study was to investigate the levels of essential trace elements in hair and serum in children with autism spectrum disorder (ASD) and investigate the age and gender effects. Children with ASD were characterized by significantly higher levels of copper (Cu) (+8%), iron (Fe) (+5%), and selenium (Se) (+13%) levels in hair and only 8% higher serum Cu levels. After stratification for gender, ASD boys were characterized by significantly increased hair Cu (+ 25%), Fe (+ 25%), and Se (+ 9%) levels, whereas in girls only Se content was elevated (+ 15%). Boys and girls suffering from ASD were characterized by significantly higher serum manganese (Mn) (+20%) and Cu (+18%) as compared to the control values, respectively. In the group of younger children (2–5 years), no significant group difference in hair trace element levels was detected, whereas serum Cu levels were significantly higher (+7%). In turn, the serum concentration of Se in ASD children was 11% lower than that in neurotypical children. In the group of older children with ASD (6–10 years), hair Fe and Se levels were 21% and 16% higher, whereas in serum only Cu levels were increased (+12%) as compared to the controls. Correlation analysis also revealed a different relationship between serum and hair trace element levels with respect to gender and age. Therefore, it is highly recommended to assess several bioindicative matrices for critical evaluation of trace element status in patients with ASD in order to develop adequate personalized nutritional correction.

Keywords

Autism Selenium Trace elements Metals Copper 

Notes

Acknowledgements

This paper was financially supported by the Ministry of Education and Science of the Russian Federation on the program to improve the competitiveness of Peoples’ Friendship University (RUDN) University among the world’s leading research and education centers in 2016 – 2020.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Anatoly V. Skalny
    • 1
    • 2
    • 3
    • 4
  • Natalia V. Simashkova
    • 5
  • Anastasia A. Skalnaya
    • 6
  • Tatiana P. Klyushnik
    • 5
  • Geir Bjørklund
    • 7
  • Margarita G. Skalnaya
    • 1
  • Alexey A. Tinkov
    • 1
    • 3
    • 8
    Email author
  1. 1.RUDN UniversityMoscowRussia
  2. 2.Orenburg State UniversityOrenburgRussia
  3. 3.Yaroslavl State UniversityYaroslavlRussia
  4. 4.Trace Element Institute for UNESCOLyonFrance
  5. 5.Scientific Center for Mental HealthRussian Academy of Medical SciencesMoscowRussia
  6. 6.Lomonosov Moscow State UniversityMoscowRussia
  7. 7.Council for Nutritional and Environmental MedicineMo i RanaNorway
  8. 8.Orenburg State Medical UniversityOrenburgRussia

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