Alcohol exposure in utero is associated with decreased gray matter volume in neonates
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Neuroimaging studies have indicated that prenatal alcohol exposure is associated with alterations in the structure of specific brain regions. However, the temporal specificity of such changes and their behavioral consequences are less known. Here we explore the brain structure of infants with in utero exposure to alcohol shortly after birth. T2 structural MRI images were acquired from 28 alcohol-exposed infants and 45 demographically matched healthy controls at 2–4 weeks of age on a 3T Siemens Allegra system as part of large birth cohort study, the Drakenstein Child Health Study (DCHS). Neonatal neurobehavior was assessed at this visit; early developmental outcome assessed on the Bayley Scales of Infant Development III at 6 months of age. Volumes of gray matter regions were estimated based on the segmentations of the University of North Carolina neonatal atlas. Significantly decreased total gray matter volume was demonstrated for the alcohol-exposed cohort compared to healthy control infants (p < 0.001). Subcortical gray matter regions that were significantly different between groups after correcting for overall gray matter volume included left hippocampus, bilateral amygdala and left thalamus (p < 0.01). These findings persisted even when correcting for infant age, gender, ethnicity and maternal smoking status. Both early neurobehavioral and developmental adverse outcomes at 6 months across multiple domains were significantly associated with regional volumes primarily in the temporal and frontal lobes in infants with prenatal alcohol exposure. Alcohol exposure during the prenatal period has potentially enduring neurobiological consequences for exposed children. These findings suggest the effects of prenatal alcohol exposure on brain growth is present very early in the first year of life, a period during which the most rapid growth and maturation occurs.
KeywordsAlcohol FASD MRI Infant Neuroimaging Dubowitz
We thank the study staff and the staff at Paarl Hospital, Mbekweni and TC Newman clinics for their support of the study. We thank the families and children who participated in this study. Funding: the study was funded by the Bill and Melinda Gates Foundation [OPP 1017641] and an ABMRF young-investigator grant, National Research Foundation, and Medical Research Council. KD was also supported by a South African Medical Association and a Harry Crossley Foundation clinical researcher grant. DJS and HJZ are supported by the Medical Research Council of South Africa.
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Conflicts of interest
The authors report no conflict of interest with respect to this work.
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