A metabonomic investigation on the biochemical perturbation in post-stroke patients with depressive disorder (PSD)
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A metabonomics study based on GC/MS and multivariate statistical analysis was performed involving 28 post stroke depressed (PSD) patients, 27 post-stroke non-depressed (PSND) patients and 33 healthy subjects to investigate the biochemical perturbation in their plasma samples. The outcome of this study showed that there was distinctive metabolic profile for PSD patients. Seven sentinel metabolites showed marked perturbations in PSD patients' blood. The introduction of metabonomics approach may provide a novel metabonomic insight about PSD and the sentinel metabolites for classifying PSD.
KeywordsMetabonomics GC/MS Stroke rehabilitation Post-stroke depression
The authors would like to thank all participants who took part in this study, and the experts at the National Center of Biomedical Analysis for providing technical assistant. This work was supported by the Chinese National Key Project of Basic Research (2009CB918301 and 2009CB918303) and the Chinese National Natural Science Foundation (81370051 and 81471155).
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Conflict of interest
The authors have declared no conflict of interest.
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