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Metabolic Brain Disease

, Volume 30, Issue 4, pp 1073–1082 | Cite as

Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice

  • Daniela D. LeffaEmail author
  • Samira S. Valvassori
  • Roger B. Varela
  • Jésica Lopes-Borges
  • Francine Daumann
  • Luiza M. Longaretti
  • Ana Luiza F. Dajori
  • João Quevedo
  • Vanessa M. Andrade
Research Article

Abstract

The consumption of palatable high-fat and high-sugar foods have increased dramatically over the past years. Overconsumption of calorically dense food contributes to increasing rates of overweight and obesity that are associated with psychiatry disorders, in particular mood and anxiety disorders. This study evaluated the impact of palatable cafeteria diet (CAF) intake on cognitive and noncognitive behaviors, as well as identified factors related to these behaviors through an evaluation of brain neurotrophic factor (BDNF, NGF, and GDNF) levels in hippocampus of mice. Male Swiss mice received two different diets during 13 weeks: standard chow (STA) and highly CAF. Posteriorly, forced swimming test (FST), tail suspension test (TST), plus-maze test (PMT), open-field tests (OFT), and object recognition task (ORT) were utilized as behavioral tests. In addition, brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) neurotrophins’ levels were evaluated in hippocampus of mice. The results demonstrated that mice from the CAF group showed a decrease in the immobility time in the FST and TST. Besides, mice in the CAF group spent more time in the open arms of the PMT. No significant differences were observed in the cognitive behaviors, which were evaluated in the OFT and ORT. In addition, the CAF group showed that BDNF and NGF protein levels increased in the hippocampus of mice. In conclusion, our data suggest that the consumption of palatable high-fat and high-sugar foods induces antidepressant- and anxiolytic-like behaviors, which can be related with BDNF and NGF expression increases in hippocampus of mice in the CAF group.

Keywords

Palatable cafeteria diet Antidepressant Anxiety Cognition BDNF NGF 

Notes

Acknowledgments

Laboratory of Neurosciences (Brazil) is a center within the National Institute for Translational Medicine (INCT-TM) and is also a member of the Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC). The authors would like to thank the Graduate Program in Health Sciences (PPGCS) and the Postgraduate Program in Cellular and Molecular Biology Applied to Health Sciences (PPG-BioSaúde) for the use of their equipment, in order to carry out this research. This research was supported by grants from National Council of Technological and Scientific Development (CNPq) and Coordination for the Improvement of Higher Education Personnel (CAPES). Center for Experimental Models in Psychiatry (USA) is funded by the Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston.

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Daniela D. Leffa
    • 1
    • 3
    Email author
  • Samira S. Valvassori
    • 2
  • Roger B. Varela
    • 2
  • Jésica Lopes-Borges
    • 2
  • Francine Daumann
    • 1
  • Luiza M. Longaretti
    • 1
  • Ana Luiza F. Dajori
    • 1
  • João Quevedo
    • 2
    • 3
  • Vanessa M. Andrade
    • 1
  1. 1.Laboratory of Molecular and Cellular Biology, Graduate Program in Health Sciences, Health Sciences UnitUniversity of Southern Santa CatarinaCriciúmaBrazil
  2. 2.Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences UnitUniversity of Southern Santa CatarinaCriciúmaBrazil
  3. 3.Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral SciencesThe University of Texas Medical School at Houston - UTHealthHoustonUSA

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