Mindfulness based cognitive therapy may improve emotional processing in bipolar disorder: pilot ERP and HRV study
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Emotional processing in bipolar disorder (BD) is impaired. We aimed to measure the effects of mindfulness based cognitive-behavioral therapy (MBCT) in BD on emotional processing, as measured by event related potentials (ERP) and by heart rate variability (HRV). ERP and HRV were recorded during the completion of a visual matching task, which included object matching, affect matching, and affect labeling. Individuals with BD (n = 12) were compared with controls (n = 9) to obtain baseline data prior to the individuals with BD undergoing an 8-week MBCT intervention. ERP and HRV recording was repeated after the MBCT intervention in BD. Participants with BD had exaggerated ERP N170 amplitude and increased HRV HF peak compared to controls, particularly during the affect matching condition. After an 8-week MBCT intervention, participants with BD showed attenuation of ERP N170 amplitude and reduced HRV HF peak. Our findings support findings from the literature emphasizing that emotional processing in BD is altered, and suggesting that MBCT may improve emotional processing in BD.
KeywordsMatching task Electroencephalography Heart rate variability Event-related potentials N170 amplitude High frequency peak Face matching
Mindfulness based cognitive therapy
Heart rate variance
Event related potential
The authors wish to thank the International Society of Affective Disorders (ISAN) for funding the present project (PIs VI-D and NRH). FMH wishes to thank the Brain and Behavior Initiative, the Research Committee of the University of Cape Town and the National Research Foundation Innovation postdoctoral fellowships during the time in which this project was conducted. The authors are also grateful to the Department of Human Genetics, and Professor Rajkumar Ramesar, for access to their research cohort, and Sister Gameda Benefeld for her time and clinical diagnoses of participants; Dr Matthew Watkins, clinical psychologist, for implementing the MBCT intervention in the present study; Ms Candice Kotze, research assistant, for her great efforts in the logistical organization and during the data collection period of the present study; and Dr Leesha Singh, psychiatrist, for her time in verifying participants’ psychiatric diagnoses. In addition, we would like to thank the research participants for their time and effort as part of this pilot study of MBCT in BD.
Authors declare that there are no conflicts of interest related to the present paper.
- Ekman P, Friesen WV (1978) Facial action coding systems (FACS): a technique for the measurement of facial action. Consulting Psychologists Press, Palo AltoGoogle Scholar
- Hassel S, Almeida JR, Kerr N, Nau S, Ladouceur CD, Fissell K, Kupfer DJ, Phillips ML (2008) Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load. Bipolar Disord 10:916–927PubMedCentralPubMedCrossRefGoogle Scholar
- Ibanez A, Urquina H, Petroni A, Baez S, Lopez V, do Nascimento M, Herrera E, Guex R, Hurtado E, Blenkmann A, Beltrachini L, Gelormini C, Sigman M, Lischinsky A, Torralva T, Torrente F, Cetkovich M, Manes F (2012) Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM). PLoS One 7:e46877PubMedCentralPubMedCrossRefGoogle Scholar
- Ives-Deliperi VL, Howells F, Stein DJ, Meintjes EM, Horn N (2013) The effects of mindfulness-based cognitive therapy in patients with bipolar disorder: a controlled functional MRI investigation. J Affect DisordGoogle Scholar
- Segal ZV, Williams JMG, Teasdale JD (2002) Mindfulness-base cognitive therapy for depression: a new approach to preventing relapseGoogle Scholar
- StatSoft Incorporated (2011) STATISTICA data analysis software system. 10Google Scholar
- Williams JM, Alatiq Y, Crane C, Barnhofer T, Fennell MJ, Duggan DS, Hepburn S, Goodwin GM (2008) Mindfulness-based cognitive therapy (MBCT) in bipolar disorder: preliminary evaluation of immediate effects on between-episode functioning. J Affect Disord 107:275–279PubMedCentralPubMedCrossRefGoogle Scholar
- WMA General Assembly (2000) World medical association declaration of Helsinki: ethical principles for medical research involving human subjects. Adopted by the 18th WMA general assembly, Helsinki, Finland, June 1964, and amended by the 52nd WMA general assembly, Edinburgh, Scotland, October 2000Google Scholar