Metabolic Brain Disease

, Volume 28, Issue 4, pp 619–627 | Cite as

Insulin resistance possible risk factor for cognitive impairment in fibromialgic patients

  • Antonietta Fava
  • Massimiliano Plastino
  • Dario Cristiano
  • Antonio Spanò
  • Stefano Cristofaro
  • Carlo Opipari
  • Antonio Chillà
  • Fatima Casalinuovo
  • Carmen Colica
  • Matteo De Bartolo
  • Domenico Pirritano
  • Domenico Bosco
Original Paper


To evaluate glucose metabolism and/or insulin resistance (IR) in 96 patients with Fibromyalgia (FM), associated or not to cognitive impairment. We investigated glucose metabolism in 96 FM patients. Enrolled patients were divided into two groups: 48 patients with memory deficit (group A) and 48 without memory deficit (control group). We evaluated glucose and insulin levels after a 2 h-Oral-Glucose-Tolerance-Test (2 h-OGTT) and insulin resistance (IR) by the homeostasis model assessment formula (HOMA). Body Mass Index (BMI), waist-to-hip-ratio (WHR), anxiety level, fasting plasma insulin and Non-Steroidal Anti-Inflammatory agents use were higher in patients with FM with memory impairment; while age, sex, waist circumference, education level, fasting plasma glucose, glycate hemoglobin, triglycerides, blood lipid profile, C- Reactivity-Protein (CRP), blood pressure and smoking habits were similar in both groups. Following OGTT the prevalence of glucose metabolism abnormalities was significantly higher in group A. IR was present in 79 % patients, of whom 23 % had also impaired glucose tolerance, 4 % newly diagnosed diabetes mellitus and 52 % IR only. Obesity and overweight prevailed in group A. IR, but not BMI or WHR was associated to an increased risk of memory impairment (OR = 2,6; 95 % CI: 1,22–3,7). The results of this study suggest that IR may represent a risk factor for memory impairment in fibromialgic patients.


Cognitive deficits Dementia Diabetes mellitus Pain syndrome Insulin resistance 



Normal Glucose Metabolism


Impaired Glucose Tolerance


Newly Diagnosed Diabetes Mellitus


Insulin Resistance


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Antonietta Fava
    • 1
  • Massimiliano Plastino
    • 2
  • Dario Cristiano
    • 2
  • Antonio Spanò
    • 2
  • Stefano Cristofaro
    • 2
  • Carlo Opipari
    • 2
  • Antonio Chillà
    • 3
  • Fatima Casalinuovo
    • 2
  • Carmen Colica
    • 4
  • Matteo De Bartolo
    • 5
  • Domenico Pirritano
    • 2
  • Domenico Bosco
    • 2
  1. 1.EndocrinologyFondazione UALSICatanzaroItaly
  2. 2.Department of Neuroscience“S. Giovanni di Dio” HospitalCrotoneItaly
  3. 3.Department of Psychiatry“S. Giovanni di Dio” HospitalCrotoneItaly
  4. 4.National Research CouncilCatanzaroItaly
  5. 5.Neurophysiology UnitHospital - RossanoRossanoItaly

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