Metabolic Brain Disease

, Volume 24, Issue 4, pp 587–597

Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats

  • Lelanie Marais
  • Dan J. Stein
  • Willie M. U. Daniels
Original Paper Original Article

DOI: 10.1007/s11011-009-9157-2

Cite this article as:
Marais, L., Stein, D.J. & Daniels, W.M.U. Metab Brain Dis (2009) 24: 587. doi:10.1007/s11011-009-9157-2


Early life stress in humans can affect the development of neurons and neurotransmitter systems and predispose an individual to the subsequent development of depression. Similarly, in rats, maternal separation causes anxiety and depressive-like behavior and decreased corticosterone levels. Patients receiving pharmacological treatment for depression often experience negative side-effects or do not respond optimally and therefore the use of exercise as alternative antidepressant treatment is investigated. The aim of the study was to see whether rats subjected to both early life stress and chronic stress later in life show differences in depressive-like behavior, neurotrophin levels, stress hormone levels and antioxidant capacity of serum after chronic voluntary exercise as treatment. Rat pups were maternally separated and one group were allowed access to running wheels for 6 weeks while control rats were also handled and put in cages without running wheels. All rats were subjected to chronic restraint stress during adulthood. A forced swim test was done to test for depressive-like behavior. Neurotrophins were measured in the ventral hippocampus and striatum; baseline stress hormones were measured in blood plasma as well as the anti-oxidative potential of serum. Compared to controls, rats that exercised had no difference in baseline stress hormones, but had decreased immobility times in the forced swim test, increased brain derived neurotrophic factor (BDNF) levels in the striatum and decreased anti-oxidative potential of their serum. The mechanism by which depressive-like behavior was improved may have been mediated through increased striatal BDNF levels, resulting in increased neuroplasticity and the prevention of neuronal death.


Maternal separation Animal models of depression Brain derived neurotrophic factor Exercise 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Lelanie Marais
    • 1
  • Dan J. Stein
    • 2
  • Willie M. U. Daniels
    • 3
  1. 1.Division of Medical PhysiologyStellenbosch UniversityTygerbergSouth Africa
  2. 2.Department of PsychiatryUniversity of Cape TownCape TownSouth Africa
  3. 3.Discipline of Human PhysiologyUniversity of Kwazulu-NatalDurbanSouth Africa

Personalised recommendations