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Metabolic Brain Disease

, Volume 24, Issue 1, pp 183–187 | Cite as

Liver transplantation and neurological side effects

  • Fuat H. SanerEmail author
  • Silvio Nadalin
  • Arnold Radtke
  • Georgios C. Sotiropoulos
  • Gernot M. Kaiser
  • Andreas Paul
Original Paper

Abstract

Advances in liver transplantation (LT), particularly in immunosuppression and intensive care treatment have had increased the number of long-term survivors following liver transplantation. In order of more long-term survivors, reports about neurological complication following liver transplantation are increasing. Neurological complications are not uncommon in liver transplant recipients, which contribute to a longer ICU- and in-hospital stay. Every effort should be focused on early detection to prevent the patient from this life-threatening event, which is often associated with poor life quality.

Keywords

Liver transplantation Immunosuppression Calcineurininhibitor Neurological complication 

Abbreviations

CNS

central nervous system

LT

liver transplantation

CSA

Cyclosporine A

TAC

Tacrolimus

CNI

Calineurininhibitor

References

  1. Adams DH et al (1987) Neurological complications following liver transplantation. Lancet 1:949–951PubMedCrossRefGoogle Scholar
  2. Estol CJ et al (1989) Seizures after liver transplantation: a clinicopathologic study. Neurology 39:1297–1301PubMedGoogle Scholar
  3. Ferreiro JA et al (1992) Neuropathologic findings after liver transplantation. Acta Neuropathol (Berl) 84:1–14CrossRefGoogle Scholar
  4. Freise CE et al (1991) Similar clinical presentation of neurotoxicity following FK 506 and cyclosporine in a liver transplant recipient. Transplant Proc 23:3173–3174PubMedGoogle Scholar
  5. Fruhauf NR et al (2003) Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation. Liver Transpl 9:983–985PubMedCrossRefGoogle Scholar
  6. Ghaus N et al (2001) Neurological complications in liver transplantation. J Neurol 248:1042–1048PubMedCrossRefGoogle Scholar
  7. Hinchey J et al (1996) A reversible posterior leukoencephalopathy syndrome. N Engl J Med 334:494–500PubMedCrossRefGoogle Scholar
  8. Kim BS et al (2007) Neurologic complications in adult living donor liver transplant recipients. Clin Transplant 21:544–547PubMedCrossRefGoogle Scholar
  9. Lewis MB, Howdle PD (2003) Neurologic complications of liver transplantation in adults. Neurology 61:1174–1178PubMedGoogle Scholar
  10. Martinez AJ (1998) The neuropathology of organ transplantation: comparison and contrast in 500 patients. Pathol Res Pract 194:473–486PubMedGoogle Scholar
  11. Menegaux F et al (1994) Neurological complications of liver transplantation in adult versus pediatric patients. Transplantation 58:447–450PubMedCrossRefGoogle Scholar
  12. McDiarmid SV et al (1995) FK506 (tacrolimus) compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Results from the U.S. Multicenter Trial. Transplantation 59:530–536PubMedCrossRefGoogle Scholar
  13. Moreno E et al (1993) Neurologic complications in liver transplantation. Acta Neurol Scand 87:25–31PubMedCrossRefGoogle Scholar
  14. Mueller AR et al (1994) Neurotoxicity after orthotopic liver transplantation. A comparison between cyclosporine and FK506. Transplantation 58:155–170PubMedGoogle Scholar
  15. Pujol A et al (1994) Predictive factors of in-hospital CNS complications following liver transplantation. Neurology 44:1226–1230PubMedGoogle Scholar
  16. Saner F et al (2006) Neurological complications after cadaveric and living donor liver transplantation. J Neurol 253:612–617PubMedCrossRefGoogle Scholar
  17. Saner FH et al (2007) Severe neurological events following liver transplantation. Arch Med Res 38:75–79PubMedCrossRefGoogle Scholar
  18. Sommer BG et al (1985) Cyclosporine-associated renal arteriopathy resulting in loss of allograft function. Am J Surg 149:756–764PubMedCrossRefGoogle Scholar
  19. Starzl TE et al (1965) Clinical experience with organ transplantation. South Med J 58:131–147PubMedGoogle Scholar
  20. Starzl TE et al (1985) Refinements in the surgical technique of liver transplantation. Semin Liver Dis 5:349–56PubMedCrossRefGoogle Scholar
  21. Stein DP et al (1992) Neurological complications following liver transplantation. Ann Neurol 31:644–649PubMedCrossRefGoogle Scholar
  22. Stracciari A, Guarino M (2001) Neuropsychiatric complications of liver transplantation. Metab Brain Dis 16:3–11PubMedCrossRefGoogle Scholar
  23. Vogt DP et al (1988) Neurologic complications of liver transplantation. Transplantation 45:1057–1061PubMedCrossRefGoogle Scholar
  24. Wijdicks EF et al (1994) FK506-induced neurotoxicity in liver transplantation. Ann Neurol 35:498–501PubMedCrossRefGoogle Scholar
  25. Wijdicks EF et al (1996) Causes and outcome of seizures in liver transplant recipients. Neurology 47:1523–1525PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Fuat H. Saner
    • 1
    Email author
  • Silvio Nadalin
    • 1
  • Arnold Radtke
    • 1
  • Georgios C. Sotiropoulos
    • 1
  • Gernot M. Kaiser
    • 1
  • Andreas Paul
    • 1
  1. 1.Department of General-, Visceral and Transplant SurgeryUniversity Hospital EssenEssenGermany

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