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Metabolic Brain Disease

, Volume 20, Issue 4, pp 359–367 | Cite as

Attention, Memory, and Cognitive Function in Hepatic Encephalopathy

  • Karin WeissenbornEmail author
  • Kathrin Giewekemeyer
  • Susanne Heidenreich
  • Martin Bokemeyer
  • Georg Berding
  • Björn Ahl
Article

Abstract

Deficits in attention and arousal play a major role in the clinical presentation of hepatic encephalopathy. Attention deficits arealso the main components of minimal hepatic encephalopathy. The present paper summarizes some findings about attentional and memory dysfunction in hepatic encephalopathy, with reference to basic knowledgeabout normal attention and memory function and their cerebral representation.

Keywords

Attention memory hepatic encephalopathy 

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References

  1. Amodio, P., Marchetti, P., Del Piccolo, F., Campo, G., Rizzo, C., Iemmolo, R.M., Gerundi, G., Caregaro, L., Merkel, C., and Gatta, A. (1998). Visual attention in cirrhotic patients: A study on covert visual attention orienting. Hepatology 27:1517–1523.PubMedCrossRefGoogle Scholar
  2. Bäumler, G. (1974). Lern- und Gedächtnistest LGT-3. Hogrefe-Verlag, Göttingen.Google Scholar
  3. Behrmann, M., Geng, J.J., and Shomstein, S. (2004). Parietal cortex and attention. Curr. Opin. Neurobiol. 14:212–217.PubMedCrossRefGoogle Scholar
  4. Brickenkamp, R. (1981). Test d2. Aufmerksamkeits-Belastungs-Test. Verlag für Psychologie J. Hogrefe, Göttingen-Toronto-Zürich.Google Scholar
  5. Bush, G., Whalen, P.J., Rosen, B.R., Jenike, M.A., McInerney, S.C., and Rauch, S.L. (1998). The counting Stroop: An interference task specialized for functional neuroimaging-validation study with functional MRI. Hum. Brain Map. 6:270–282.CrossRefGoogle Scholar
  6. Calabrese, P., and Markowitsch, H.J. (2003). Gedächtnis und Gehirn—Neurobiologische Korrelate von Gedächtnisstörungen. Fortschr. Neurol. Psychiat. 71:211–219.PubMedGoogle Scholar
  7. Christensen, A.L. (1979). Luria's Neuropsychological Investigation, Text, 2nd edn., Munksgaard, Copenhagen.Google Scholar
  8. Coull, J.T., Frith, C.D., Frackowiak, R.S.J., and Grasby, P.M. (1996). A fronto-parietal network for rapid visual information processing: A PET study of sustained attention and working memory. Neuropsychologia 34:1085–1095.Google Scholar
  9. Davidson, M.C., and Marrocco, R.T. (2000). Local infusion of scopolamine into intraparietal cortex alters covert orienting in rhesus monkeys. J. Neurophysiol. 83:1536–1549.PubMedGoogle Scholar
  10. Eichenbaum, H. (2000). A cortical–hippocampal system for declarative memory. Nat. Rev. Neurosci. 1(1):41–50.PubMedCrossRefGoogle Scholar
  11. Ferenci, P., Lockwood, A.H., Mullen, K., Tarter, R., Weissenborn, K., and Blei, A.T. (2002). Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: Final report of the working party at the 11th World Congress of Gastroenterology, Vienna 1998. Hepatology 35(3):716–721.Google Scholar
  12. Fernandez-Duque, D., and Posner, M.I. (2001). Brain imaging of attentional networks in normal and pathological states. J. Clin. Exp. Neuropsychol. 23(1):74–93.PubMedGoogle Scholar
  13. Filley, C.M. (2002). The neuroanatomy of attention. Semin. Speech Lang. 23(2):89–98.PubMedCrossRefGoogle Scholar
  14. Lockwood, A.H., Weissenborn, K., Bokemeyer, M., Tietge, U., and Burchert, W. (2002). Correlations between cerebral glucose metabolism and neuropsychological test performance in non-alcoholic cirrhotics. Metab. Brain Dis. 17(1):29–40.PubMedCrossRefGoogle Scholar
  15. Markowitsch, H.J. (2000). Anatomical basis of memory disorders. In (M.S. Gazzaniga, ed.), The New Cognitive Neurosciences, 2nd edn., MIT Press, Cambridge, MA, pp. 781–795.Google Scholar
  16. Mesulam, M.-M. (2000). Attentional networks, confusional states, and neglect syndromes. In (M.-M. Mesulam, ed.), Principles of Behavioral and Cognitive Neurology, 2nd edn., Oxford University Press, Oxford, pp. 174–256.Google Scholar
  17. Osterreith, P. (1944). Le test de copie d'une figure complexe. Arch. Psychol. 30:206–356.Google Scholar
  18. Plum, F., and Posner, J.B. (1982). The Diagnosis of Stupor and Coma, F.A. Davis, Philadelphia.Google Scholar
  19. Posner, M.I., and DiGirolamo, G.J. (1998). Conflict, target detection, and cognitive control. In (R. Parasuraman, ed.), The Attentive Brain, MIT Press, Cambridge, MA, pp. 401–424.Google Scholar
  20. Posner, M.I., and Peterson, S.E. (1990). The attention system of the human brain. Ann. Rev. Neurosci. 13:25–42.PubMedCrossRefGoogle Scholar
  21. Rixecker, H., and Hartje, W. (1980). Kimura's recurring-figures-test: A normative study. J. Clin. Psychol. 36:465–467.PubMedGoogle Scholar
  22. Schomerus, H., Weissenborn, K., Hamster, W., Rückert, N., and Hecker, H. (1999). PSE-Syndrom-Test. Psychodiagnostisches Verfahren zur quantitativen Erfassung der (minimalen) portosystemischen Enzephalopathie. Swets Test Services, Frankfurt.Google Scholar
  23. Sherlock, S., Summerskill, W.H.J., White, L.P., and Phear, E.A. (1954). Portal-systemic encephalopathy. Neurological complications of liver disease. Lancet I:453–457.Google Scholar
  24. Smith, A., and Nutt, D. (1996). Noradrenalin and attention lapses. Nature 380:291.PubMedGoogle Scholar
  25. Sturm, W., Willmes, K., Orgass, B., and Hartje, W. (1997). Do specific attention deficits need specific training? Neurol. Rehabil. 12:81–103.Google Scholar
  26. Swanson, J., Castellanos, F.X., Murias, M., LaHoste, G., and Kennedy, J. (1998). Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder. Curr. Opin. Neurobiol. 8:263–271.PubMedCrossRefGoogle Scholar
  27. Tewes, U. (1991). HAWIE-R. Hamburg-Wechsler-Intelligenztest für Erwachsene, Revision, Verlag Hans Huber, Bern-Stuttgart-Toronto.Google Scholar
  28. Weissenborn, K., Ennen, J.C., Schomerus, H., Rückert, N., and Hecker, H. (2001a). Neuropsychological characterization of hepatic encephalopathy. J. Hepatol. 34:768–773.CrossRefGoogle Scholar
  29. Weissenborn, K., Heidenreich, S., Ennen, J., Rückert, N., and Hecker, H. (2001b). Attention deficits in minimal hepatic encephalopathy. Metab. Brain Dis. 16(1/2):13–19.CrossRefGoogle Scholar
  30. Weissenborn, K., Heidenreich, S., Giewekemeyer, K., Rückert, N., and Hecker, H. (2003). Memory function in early hepatic encephalopathy. J. Hepatol. 39(3):320–325.PubMedCrossRefGoogle Scholar
  31. Weissenborn, K., Rückert, N., Brassel, F., Becker, H., and Dietz, H. (1996). A proposed modification of the Wada test for presurgical assessment in temporal lobe epilepsy. Neuroradiology 38:422–429.PubMedGoogle Scholar
  32. Witte, E.A., and Marrocco, R.T. (1997). Alteration of brain noradrenergic activity in rhesus monkeys affects the alerting component of covert orienting. Psychopharmacology 132:315–323.PubMedGoogle Scholar
  33. Zimmermann, P., and Fimm, B. (1989). Neuropsychologische Testbatterie zur Erfassung von Aufmerk samkeitsdefiziten—Revidierte Fassung, Psychologisches Institut der Universität Freiburg, Freiburg.Google Scholar

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Karin Weissenborn
    • 2
    • 4
    Email author
  • Kathrin Giewekemeyer
    • 2
  • Susanne Heidenreich
    • 2
  • Martin Bokemeyer
    • 2
    • 1
  • Georg Berding
    • 3
  • Björn Ahl
    • 2
  1. 1.Department of Neurology, Medizinische Hochschule HannoverHannoverGermany
  2. 2.Department of Neuroradiology, Medizinische Hochschule HannoverHannoverGermany
  3. 3.Department of Nuclear Medicine, Medizinische Hochschule HannoverHannoverGermany
  4. 4.Department of Neurology, Medizinische Hochschule HannoverHannoverGermany

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