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Molecular and Cellular Biochemistry

, Volume 450, Issue 1–2, pp 209–210 | Cite as

Correction to: ACE2, CALM3 and TNNI3K polymorphisms as potential disease modifiers in hypertrophic and dilated cardiomyopathies

  • Amit Kumar
  • Bindu Rani
  • Rajni Sharma
  • Gurjeet Kaur
  • Rishikesh Prasad
  • Ajay Bahl
  • Madhu KhullarEmail author
Correction
  • 103 Downloads

Correction to: Mol Cell Biochem (2018) 438:167–174  https://doi.org/10.1007/s11010-017-3123-9

In the original publication of the article, the location and rs number of TNNI3K mouse SNP (3784 C>T) (rs49812611) has been mentioned inadvertently in place of its human homologue. The correct information for human SNP is rs760769780 located at position 74436534, resulting in (G>A) change in human TNNI3K gene.

Therefore, TNNI3K (3784 C>T, rs 49812611) should be read as TNNI3K 74436534 G>A, rs number 760769780 in the text. The correct rs number (760769780) and location of gene (74436534) have been provided in the corrected Tables 2 and 3.

Table 2

Genotype frequency of ACE2, TNNI3K and CALM3 genes in HCM, DCM patients and controls

Polymorphisms

HCM (n = 130)

Control (n = 236)

OR (95% CI)

p value

ACE2 (7160726 C>G)

CC = 81 (62.3)

CC = 146 (61.9)

0.86 (0.53–1.40)

0.62

CG = 36 (27.7)

CG = 75 (31.8)

1.56 (0.71–3.44)

0.30

GG = 13 (10)

GG = 15 (6.4)

TNN13K (74436534 G>A)

GG = 77 (62.3)

GG = 161 (68.2)

1.19 (0.74–1.89)

0.47

GA = 42 (32.3)

GA = 74 (31.4)

23(2.91–181.38)

0.000056

AA = 11 (8.5)

AA = 01 (0.4)

CALM3 (−34T>A)

TT = 68 (52.3)

TT = 151 (63.7)

1.32 (0.84–2.08)

0.25

TA = 51 (39.2)

TA = 86 (36.3)

Infinite

0.000048

AA = 11 (8.5)

AA = 0 (0)

Polymorphisms

DCM (n = 161)

Control (n = 236)

OR (95% CI)

p value

ACE2 (7160726 C>G)

CC = 116 (72)

CC = 133 (56.4)

0.63 (0.40–1.00)

0.05

CG = 41 (25.5)

CG = 74 (31.4)

0.15 (0.05–0.46)

0.0001

GG = 4 (2.5)

GG = 29 (12.30)

TNN13K (74436534 G>A)

GG = 111 (68.9)

GG = 161 (68.2)

0.8 (0.51–1.26)

0.36

GA = 41 (25.5)

GA = 74 (31.4)

13.05(1.63–104.50)

0.002

AA = 9 (5.6)

AA = 1 (0.4)

CALM3 (−34T>A)

TT = 99 (61.5)

TT = 151 (63.7)

0.89 (0.58–1.38)

0.66

TA = 50 (31.1)

TA = 86 (36.3)

Infinite

0.000023

AA = 12 (7.5)

AA = 0 (0)

Table 3

ACE2, TNNI3K and CALM3 gene allele frequencies in HCM and DCM patients and controls

Polymorphisms

HCM (n = 130)

Control (n = 236)

OR (95% CI)

p value

ACE2 (7160726 C>G)

C = 198 (0.76)

C = 367 (0.78)

1.09 (0.76–1.57)

0.64

G = 62 (0.24)

G = 105 (0.22)

TNN13K (74436534 G>A)

G = 196 (0.75)

G = 396 (0.84)

1.70 (1.17–2.47)

0.005

A = 64 (0.25)

A = 76 (0.16)

CALM3 (−34T>A)

T = 187 (0.72)

T = 387 (0.82)

1.76 (1.23–2.52)

0.002

A = 73 (0.28)

A = 85 (0.18)

Polymorphisms

DCM (n = 161)

Control (n = 236)

OR (95% CI)

p value

ACE2 (7160726 C>G)

C = 273 (0.85)

C = 340 (0.72)

0.46 (0.32–0.66)

0.00003

G = 49 (0.15)

G = 132 (0.28)

TNN13K (74436534 G>A)

G = 396 (0.84)

G = 263 (0.82)

1.17 (0.80–1.69)

0.44

A = 76 (0.16)

A = 59 (0.18)

CALM3 (−34T>A)

T = 248 (0.77)

T = 388 (0.82)

1.36 (0.95–1.93)

0.08

A = 74 (0.23)

A = 86 (0.18)

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Amit Kumar
    • 1
  • Bindu Rani
    • 1
  • Rajni Sharma
    • 2
  • Gurjeet Kaur
    • 4
  • Rishikesh Prasad
    • 1
  • Ajay Bahl
    • 3
  • Madhu Khullar
    • 1
    Email author
  1. 1.Department of Experimental Medicine and BiotechnologyPGIMERChandigarhIndia
  2. 2.Department of OtolaryngologyPGIMERChandigarhIndia
  3. 3.Department of CardiologyPGIMERChandigarhIndia
  4. 4.Department of EndocrinologyPGIMERChandigarhIndia

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