Molecular and Cellular Biochemistry

, Volume 450, Issue 1–2, pp 97–103 | Cite as

Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer

  • Yanfei Jia
  • Shuhua Hao
  • Guangchao Jin
  • Hongyu Li
  • Xiaoli Ma
  • Yan Zheng
  • Dongjie XiaoEmail author
  • Yunshan WangEmail author


Aryl hydrocarbon-receptor nuclear translocator (ARNT2) is a member of the bHLH PAS (basic helix–loop–helix Period/ARNT/Single-minded) family of transcription factors. Recently, some studies indicate that ARNT2 is associated with the occurrence and development of carcinoma. However, its roles in gastric cancer (GC) remain unclear. In the present study, we found that ARNT2 expression level is lower in GC tissues compared with adjacent non-tumor tissues, and negatively correlated with depth of invasion of the tumor, differentiated degree, and poor survival of GC patients. Overexpression of ARNT2 inhibits cell proliferation. Furthermore, AKT pathway contributed to ARNT2 -mediated PC proliferation. Taken together, our results provide the first evidence that high expression of ARNT2 inhibited proliferation of GC cells and affected tumor aggressiveness in GC patients.


Aryl hydrocarbon-receptor nuclear translocator (ARNT2) Gastric cancer (GC) Proliferation 



This work was financially supported by the National Natural Science Foundation of China (No. 31671468 and 81602593), the Chinese Postdoctoral Science Foundation (No. 2016M602152), the Shandong Provincial Natural Science Foundation of China (No. 2016ZRA01062, ZR2015HM018, ZR2017MH071, and ZR2012HM061), and the Jinan Postdoctoral Innovation Project (172634).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Authors and Affiliations

  1. 1.Central LaboratoryJinan Central Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China
  2. 2.Genetic laboratoryWomen and Children’s Health Care Hospital of LinyiLinyiPeople’s Republic of China
  3. 3.Department of Breast SurgeryJinan Central Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China
  4. 4.School of Medicine and Life SciencesUniversity of Jinan-Shandong Academy of Medical SciencesJinanPeople’s Republic of China
  5. 5.Shandong Province Key Lab of Tumor Target MoleculeJinan Central Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China

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