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Molecular and Cellular Biochemistry

, Volume 437, Issue 1–2, pp 119–131 | Cite as

Regulation of cardiac myocyte cell death and differentiation by myocardin

  • Joseph W. Gordon
Article

Abstract

Myocardin is a cardiac- and smooth muscle-enriched transcriptional co-activator that was originally described as an interacting partner of the serum response factor. Shortly after myocardin’s discovery, a wealth of published literature described the role of myocardin as a regulator of smooth muscle differentiation and phenotype modulation, while gene-targeting studies confirmed the essential role of myocardin in vascular development. More recently, myocardin has been implicated as an important regulator of cardiac myocyte differentiation in studies demonstrating direct programming of fibroblasts towards the cardiac lineage. This function of myocardin has been attributed to its physical interaction with cardiac-enriched transcription factors such as MEF2C, GATA4, and TBX5. Moreover, conditional knockout models have revealed a critical role for myocardin during cardiac chamber maturation, and a surprising function for myocardin in the regulation of cardiomyocyte proliferation, cell death, and possibly mitochondrial function. This review summarizes the literature surrounding the cardiac-specific roles of myocardin during development and post-natal cardiac remodeling. In addition, we take a bioinformatics and computational approach to discuss known and predicted interactions and biological functions of myocardin, which suggests areas for future research.

Keywords

Myocardin Heart Cardiac development Heart disease 

Notes

Acknowledgements

JWG is supported by the Natural Science and Engineering Research Council (NSERC) Canada and the Children’s Hospital Foundation of Manitoba. JWG is a member of the DEVOTION Research Cluster.

Compliance with ethical standards

Conflict of interest

None.

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Authors and Affiliations

  1. 1.Department of Human Anatomy and Cell ScienceUniversity of ManitobaWinnipegCanada
  2. 2.College of Nursing, Rady Faculty of Health ScienceUniversity of ManitobaWinnipegCanada
  3. 3.Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme of the Children’s Hospital Research Institute of ManitobaUniversity of ManitobaWinnipegCanada

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