Polymorphism of catechol-o-methyltransferase and uterine leiomyoma
- 305 Downloads
Uterine leiomyoma (ULM) is the most common gynecological benign tumor that is affecting around 20–50 % of women over the age of 30. Although its molecular pathogenesis is still unknown, ULM has a multifactorial etiology determined by both genetics and environmental factors. The present study was designed to find out whether Val158Met polymorphism in the catechol-o-methyltransferase (COMT) gene is associated with the risk of ULM. We analyzed COMT Val158Met polymorphism in 105 ULMs patients and 105 healthy subjects using a polymerase chain reaction-based restriction fragment length polymorphism assay. We found remarkably similar frequencies in ULM compared with controls for COMT Val158Met genotypes and alleles, and no association was found between ULM and this polymorphism (p = 0.46). The COMT 158 Met allele in patients with large (≥5 cm) fibroids was higher than in patients with small (<5 cm) fibroids, and significant association was found between fibroid size and COMT 158 Met allele (p = 0.011, OR 0.50, 95 %CI 0.28–0.90). Our results reflect that COMT Val158Met polymorphism is not associated with an increased risk of ULMs, but Val158Met polymorphism may be a risk factor for development of large fibroids in Turkish patients with ULM.
KeywordsCOMT Uterine leiomyoma Genetic susceptibility Polymorphism
This work was supported by the Gaziosmanpasa University Scientific Research Projects Fund, Project numbers 2011/93.
Conflict of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
- 6.Ivanova TI, Kondrashova TV, Krikunova LI, Smirnova IA, Shentereva NI, Sychenkova NI, Rykova EV, Zharikova IA, Khorokhorina VA, Riabchenko NI, Zamulaeva IA (2010) The polymorphism of catechol-o-methyltransferase (COMT) and hemochromatosis (HFE) genes in the radiocontaminated regions residents with different chromosome aberration frequency. Radiats Biol Radioecol 50:117–127PubMedGoogle Scholar
- 14.Denschlag D, Bentz EK, Hefler L, Pietrowski D, Zeillinger R, Tempfer C, Tong D (2006) Genotype distribution of estrogen receptor-alpha, catechol-o-methyltransferase, and cytochrome P450 17 gene polymorphisms in Caucasian women with uterine leiomyomas. Fertil Steril 85:462–467PubMedCrossRefGoogle Scholar
- 19.Myers E, Barber M, Couchman G et al (2001) Management of uterine fibroids. AHRQ Publication No. 01-E052. In: Vol. 1, AHRQ Evidence Reports, No. 24Google Scholar