Molecular and Cellular Biochemistry

, Volume 374, Issue 1–2, pp 157–161

Interleukin-8 stimulates progesterone production via the MEK pathway in ovarian theca cells

  • Takashi Shimizu
  • Eri Imamura
  • Fumie Magata
  • Chiaki Murayama
  • Akio Miyamoto


Interleukin 8 (IL-8) is a chemoattractant associated with ovulation in the mammalian ovary. This chemokine is also involved in the recruitment and activation of neutrophils. Using bovine tissue, we examined the possible role of IL-8 in steroid production by theca cells of the large ovarian follicles. IL-8 promoted progesterone production and stimulated StAR expression in cultured theca cells. The inhibitor of p38 did not disturb the P4 production and StAR expression in IL-8-treated theca cells. On the other hand, the inhibitor of MEK disturbed the P4 production and expression of StAR in theca cells treated with IL-8. These results suggest that IL-8 is associated with progesterone production in bovine theca cells via the MEK pathway.


IL-8 Progesterone StAR p38 MEK Theca cell 


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Takashi Shimizu
    • 1
  • Eri Imamura
    • 1
  • Fumie Magata
    • 1
  • Chiaki Murayama
    • 1
  • Akio Miyamoto
    • 1
  1. 1.Graduate School of Animal and Food HygieneObihiro University of Agriculture and Veterinary MedicineObihiroJapan

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