Molecular and Cellular Biochemistry

, Volume 364, Issue 1–2, pp 345–350 | Cite as

Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

  • Gaoxiang Jia
  • Ling Su
  • Sunil Singhal
  • Xiangguo LiuEmail author


With the characterization of Sir2 gene in yeast aging, its mammalian homologs Sirtuins 1–7 have been attracting attention from scientists with various research backgrounds. Among Sirtuins, SIRT1 is the most extensively studied. Recent progress on mammalian Sirtuins has shown that SIRT6 as a histone deacetylase may also play a critical role in regulating mammalian aging. This review summarizes recent advances on SIRT6 as a key modulator of telomere structure, DNA repair, metabolism, and NF-kappa B pathway in aging. In addition, we discuss the challenges that remain to be studied in SIRT6 biology.


SIRT6 Telomere structure DNA repair Metabolism Mammalian aging 


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Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Gaoxiang Jia
    • 1
  • Ling Su
    • 1
  • Sunil Singhal
    • 2
  • Xiangguo Liu
    • 1
    Email author
  1. 1.Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life SciencesShandong UniversityJinanPeople’s Republic of China
  2. 2.Division of Thoracic Surgery, Department of SurgeryUniversity of PennsylvaniaPhiladelphiaUSA

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