Molecular and Cellular Biochemistry

, Volume 353, Issue 1–2, pp 59–63

Lipid profiles and oxidative stress parameters in male and female hemodialysis patients

  • A. Osorio
  • E. Ortega
  • T. de Haro
  • J. M. Torres
  • P. Sánchez
  • E. Ruiz-Requena
Article

DOI: 10.1007/s11010-011-0774-9

Cite this article as:
Osorio, A., Ortega, E., de Haro, T. et al. Mol Cell Biochem (2011) 353: 59. doi:10.1007/s11010-011-0774-9

Abstract

To study atherogenesis markers in patients with stage 5D chronic kidney disease (CKD-5D) on hemodialysis to determine which parameters are modified and whether their behavior differ between male and female patients of similar age. Total cholesterol, triglycerides, glucose, total proteins, HDL-cholesterol, LDL-cholesterol, oxidative modification of low-density lipoprotein-cholesterol, autoantibodies against oxidized low-density lipoproteins-cholesterol, homocysteine (Hcy), folate, and vitamin B12 were measured in male and female controls and CKD-5D patients on hemodialysis for >6 months. The CKD-5D patients had significantly lower cholesterol, LDL-c and ox-LDL levels and significantly higher ox-LDL-AB and Hcy levels versus their respective controls. The reduction in ox-LDL in CKD patients does not imply a lower risk of atherosclerosis. In fact, the risk may be higher due to a greater capture of ox-LDL by macrophage scavenger receptors, which are increased in these patients. Elevated Hcy levels may also be a risk factor for atherosclerosis in male and female CKD-5D patients.

Keywords

Atherosclerosis CKD Homocysteine LDL Ox-LDL Ox-LDL-AB 

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • A. Osorio
    • 1
  • E. Ortega
    • 2
    • 3
  • T. de Haro
    • 4
  • J. M. Torres
    • 2
    • 3
  • P. Sánchez
    • 2
  • E. Ruiz-Requena
    • 2
  1. 1.Unit of Vascular SurgeryHospital Virgen de la LuzCuencaSpain
  2. 2.Department of Biochemistry and Molecular Biology, Faculty of MedicineUniversity of GranadaGranadaSpain
  3. 3.Institute of NeurosciencesUniversity of GranadaGranadaSpain
  4. 4.Section of Clinical BiochemistrySan Cecilio University HospitalGranadaSpain

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