Molecular and Cellular Biochemistry

, Volume 350, Issue 1–2, pp 113–118 | Cite as

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population

  • Hamzeh Saberi
  • Narges Mohammadtaghvaei
  • Shekufeh Gulkho
  • Salar Bakhtiyari
  • Mohammad Mohammadi
  • Parichehr Hanachi
  • Siavash Gerayesh-nejad
  • Mehryar Zargari
  • Farangis Ataei
  • Leila Parvaneh
  • Bagher Larijani
  • Reza MeshkaniEmail author


The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been variably associated with insulin resistance and type 2 diabetes (T2D) in several populations. However, this association has not been studied in Iranian subjects and we hypothesized that the K121Q variant might be associated with T2D and related metabolic traits in this population. The K121Q genotypes were determined by PCR-restriction fragment length polymorphism in 377 normoglycemic controls and 155 T2D patients. T2D patients had significantly higher values for systolic and diastolic blood pressure, BMI, glucose, cholesterol, triglyceride, LDL, apoB, insulin, and HOMA-IR, and lower levels of HDL than the normoglycemic subjects. The frequency of the Q allele did not differ between T2D and normoglycemic subjects (OR 0.96, 95% CI 0.90–2.00, P = 0.70). The Q allele frequency was 16.5% in T2D and 15.2% in normoglycemic subjects. The ENPP1 genotype (KQ + QQ) was not associated with the systolic and diastolic blood pressure, glucose, triglyceride, cholesterol, LDL-C and HDL-C, apo B, BMI, HOMA-IR, and insulin levels in both normoglycemic and T2D groups. Our results suggest that the ENPP1 121Q allele might not be associated with T2D and related metabolic traits among Iranian subjects.


Insulin resistance Iranian population Type 2 diabetes K121Q ENPP1 


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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Hamzeh Saberi
    • 1
  • Narges Mohammadtaghvaei
    • 2
  • Shekufeh Gulkho
    • 3
  • Salar Bakhtiyari
    • 4
  • Mohammad Mohammadi
    • 5
  • Parichehr Hanachi
    • 6
  • Siavash Gerayesh-nejad
    • 7
  • Mehryar Zargari
    • 8
  • Farangis Ataei
    • 9
  • Leila Parvaneh
    • 10
  • Bagher Larijani
    • 11
  • Reza Meshkani
    • 7
    Email author
  1. 1.Department of Biology, Science and Research BranchIslamic Azad UniversityTehranIslamic Republic of Iran
  2. 2.Department of Clinical Biochemistry, Faculty of MedicineAhwaz Jundi-Shapour University of Medical SciencesAhwazIslamic Republic of Iran
  3. 3.Biomedical Laboratory, Women Research CenterAl-Zahra UniversityTehranIslamic Republic of Iran
  4. 4.Department of Clinical Biochemistry, School of MedicineIlam University of Medical SciencesIlamIran
  5. 5.Department of Biology, Faculty of ScienceShahid Chamran UniversityAhwazIslamic Republic of Iran
  6. 6.Department of Biology, Faculty of Basic SciencesAlzahra UniversityTehranIslamic Republic of Iran
  7. 7.Department of Biochemistry, Faculty of MedicineTehran University of Medical SciencesTehranIslamic Republic of Iran
  8. 8.Department of Biochemistry and Genetic, Faculty of MedicineMazandaran University of Medical SciencesSariIslamic Republic of Iran
  9. 9.Department of Biochemistry, Faculty of Biological SciencesTarbiat Modares UniversityTehranIslamic Republic of Iran
  10. 10.Department of Clinical Biochemistry, Faculty of Medical SciencesTarbiat Modares UniversityTehranIslamic Republic of Iran
  11. 11.Endocrinology and Metabolism Research Centre, Shariati HospitalTehran University of Medical SciencesTehranIslamic Republic of Iran

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