Molecular and Cellular Biochemistry

, Volume 322, Issue 1–2, pp 193–206

Novel role of toll-like receptor 3, RIG-I and MDA5 in poly (I:C) RNA-induced mesothelial inflammation

  • Markus Wörnle
  • Matthias Sauter
  • Kathrin Kastenmüller
  • Andrea Ribeiro
  • Maximilian Roeder
  • Holger Schmid
  • Florian Krötz
  • Thomas Mussack
  • Roland Ladurner
  • Thomas Sitter
Article

DOI: 10.1007/s11010-008-9957-4

Cite this article as:
Wörnle, M., Sauter, M., Kastenmüller, K. et al. Mol Cell Biochem (2009) 322: 193. doi:10.1007/s11010-008-9957-4

Abstract

Viral inflammation and infection of mesothelial cells (MC) are a major problem in several organ systems including pleura, pericardium and peritoneum. Toll-like receptors (TLRs) are an essential part of the innate immune system for early recognition of pathogen-associated molecular patterns. TLRs recognise molecular patterns associated with microbial pathogens and induce an immune response. TLR3 recognises dsRNA of viral origin as exemplified by poly (I:C) RNA, a synthetic analogue of viral dsRNA. The helicases RIG-I and MDA5 may also act as sensors of viral infections. MC exhibit an expression of TLR3, RIG-I and MDA5. Poly (I:C) RNA stimulation resulted in an up-regulation of proinflammatory cytokines and chemokines as well as type I interferons. This novel finding of functional expression of viral sensors on human MC may indicate a novel link between viral infections and mesothelial inflammation and indicates a pathophysiologic role of viral receptors in these processes.

Keywords

Chemokines Cytokines Inflammation Lung Viral 

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Markus Wörnle
    • 1
  • Matthias Sauter
    • 1
  • Kathrin Kastenmüller
    • 1
  • Andrea Ribeiro
    • 1
  • Maximilian Roeder
    • 1
  • Holger Schmid
    • 1
  • Florian Krötz
    • 1
  • Thomas Mussack
    • 2
  • Roland Ladurner
    • 2
  • Thomas Sitter
    • 1
  1. 1.Medical PoliclinicLudwig-Maximilians-UniversityMunichGermany
  2. 2.Department of SurgeryLudwig-Maximilians-UniversityMunichGermany

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