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Molecular and Cellular Biochemistry

, Volume 317, Issue 1–2, pp 131–135 | Cite as

Regulation of CD163 associated casein kinase II activity is haptoglobin genotype dependent

  • Merav Strauss
  • Andrew P. Levy
Article

Abstract

Free hemoglobin is now recognized as a major mediator of a variety of vascular diseases. The abundant serum protein haptoglobin irreversibly binds to hemoglobin and promotes the uptake of hemoglobin via the macrophage CD163 receptor. The haptoglobin gene is polymorphic in man with two common alleles denoted 1 and 2. The haptoglobin genotype specifies the nature of the response of the macrophage to free hemoglobin. Hp 1-Hb complexes stimulate an anti-inflammatory macrophage phenotype while Hp 2-Hb complexes do not. We have previously demonstrated that Hp 1-Hb induced anti-inflammatory cytokine production is critically dependent on casein kinase II. In this study we set out to determine whether the amount or the activity of casein kinase II associated with CD163 was altered by the binding of Hp 1-1-Hb to CD163. Our results indicate that casein kinase II activity is increased by the binding of Hp 1-1-Hb to CD163.

Keywords

Haptoglobin Hemoglobin CD163 Casein kinase II 

Notes

Acknowledgments

This work was supported by grants from the US-Israel Binational Science Foundation and the Israel Science Foundation to APL.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  1. 1.Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael

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