Molecular and Cellular Biochemistry

, Volume 310, Issue 1–2, pp 209–214 | Cite as

Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine

  • Sivapatham Sundaresan
  • Perumal Subramanian


Chemopreventive effect of S-allylcysteine (constituent of garlic) on N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis was evaluated in Wistar rats. Significantly decreased lipid peroxidation products (thiobarbituric acid reactive substances-TBARS and lipid hydroperoxides) with increased level of reduced glutathione, increased activities of glutathione S-transferase, and glutathione peroxidase were observed in liver of NDEA-treated rats when compared with control rats. The activities of superoxide dismutase and catalase were significantly decreased in tumor tissue when compared with control. Administration of S-allylcysteine (SAC) showed the inhibition of tumor incidence, modulated the lipid peroxidation, and increased the reduced glutathione, glutathione-dependent enzymes, superoxide dismutase, and catalase in NDEA-induced carcinogenesis. From our results, we speculate that S-allylcysteine mediates its chemopreventive effects by modulating lipid peroxidation, GST stimulation, and by increasing the antioxidants. Hence SAC prevents cells from loss of oxidative capacity in NDEA-induced hepatocarcinogenesis.


Antioxidants Hepatocarcinogenesis Lipid peroxidation Nitrosodiethylamine S-allylcysteine 


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© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  1. 1.Department of Biochemistry and Biotechnology, Faculty of ScienceAnnamalai UniversityAnnamalai NagarIndia

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