Beneficial effects of ketogenic diet in obese diabetic subjects
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Obesity is closely linked to the incidence of type II diabetes. It is found that effective management of body weight and changes to nutritional habits especially with regard to the carbohydrate content and glycemic index of the diet have beneficial effects in obese subjects with glucose intolerance. Previously we have shown that ketogenic diet is quite effective in reducing body weight. Furthermore, it favorably alters the cardiac risk factors even in hyperlipidemic obese subjects. In this study the effect of ketogenic diet in obese subjects with high blood glucose level is compared to those with normal blood glucose level for a period of 56 weeks.
Materials and methods
A total of 64 healthy obese subjects with body mass index (BMI) greater than 30, having high blood glucose level and those subjects with normal blood glucose level were selected in this study. The body weight, body mass index, blood glucose level, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, urea and creatinine were determined before and at 8, 16, 24, 48, and 56 weeks after the administration of the ketogenic diet.
The body weight, body mass index, the level of blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and urea showed a significant decrease from week 1 to week 56 (P < 0.0001), whereas the level of HDL-cholesterol increased significantly (P < 0.0001). Interestingly these changes were more significant in subjects with high blood glucose level as compared to those with normal blood glucose level. The changes in the level of creatinine were not statistically significant.
This study shows the beneficial effects of ketogenic diet in obese diabetic subjects following its long-term administration. Furthermore, it demonstrates that in addition to its therapeutic value, low carbohydrate diet is safe to use for a longer period of time in obese diabetic subjects.
KeywordsObesity Blood glucose Cholesterol LDL HDL Triglycerides Low-carbohydrate diet Ketogenic diet
We would like to thank Mrs. Elizabeth Mathew, Department of Anatomy for expert technical advice and assistance.
- 1.Bray GA (1976) The risks and disadvantages of obesity. The obese patient. Saunders, Philadelphia, pp 215–251Google Scholar
- 6.National Diabetes Commission (1976) Report of the National Diabetes Commission on Diabetes to the Congress of the United States. Washington, DC, U.S. Govt. Printing Office, (DHEW publ. no. 1:1019)Google Scholar
- 7.Colditz GA (1995) The Nurses’ Health Study: a cohort of US women followed since 1976. J Am Med Women’s Assoc 50:40–44Google Scholar
- 13.Molavi B, Rasouli N, Kern PA (2006) The prevention and treatment of metabolic syndrome and high-risk obesity Curr Opin Cardiol 21:479–485Google Scholar
- 15.Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laasko M, Louheranta A, Rastas M, Salminen V, Uusitupa M (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343–1350PubMedCrossRefGoogle Scholar
- 17.Dashti HM, Mathew TC, Hussein T, Asfar SK, Behbehani AI, Al-Sayer HM, Al-Zaid NS. (2004) Long term effects of ketogenic diet in obese subjects. Exp Clin Cardiol 9(3): 200–205Google Scholar
- 36.La Vecchia C (2004) Mediterranean diet and cancer. Public Health Nutr (7):965–968Google Scholar
- 37.Shahtahmasebi S, Shahtahmasebi S (2004) A case follow-up report: possible health benefits of extra virgin olive oil. Scientific World J 4:853–858Google Scholar