Molecular and Cellular Biochemistry

, Volume 290, Issue 1–2, pp 199–204

Ala45Thr variation in neuroD1 gene is associated with early-onset type 2 diabetes with or without diabetic pedigree in Chinese

  • Limei Liu
  • Weiping Jia
  • Taishan Zheng
  • Ming Li
  • Huijuan Lu
  • Kunsan Xiang
Article

DOI: 10.1007/s11010-006-9217-4

Cite this article as:
Liu, L., Jia, W., Zheng, T. et al. Mol Cell Biochem (2006) 290: 199. doi:10.1007/s11010-006-9217-4

Abstract

Objective: Based on onset-age stratified analysis may be useful to determine the association of NeuroD1-Ala45Thr variation with susceptibility to genetic heterogeneous type 2 diabetes mellitus (T2DM), we investigated the Ala45Thr variation in unrelated early-onset and late-onset T2DM with or without diabetic pedigree and unrelated non-diabetic control subjects in Chinese.

Methods: 175 early-onset and 194 late-onset type 2 diabetic patients were further divided into two subgroups according to with or without diabetic pedigree respectively. This NeuroD1-Ala45Thr variation were screened by PCR-direct sequencing in above 369 type 2 diabetic patients and 87 unrelated non-diabetic control subjects. We then compared the distribution of the Ala45Thr variation among the groups, searching for the predictive trends.

Results: Frequencies of the variant (AA + GA genotype) in early-onset T2DM are obviously elevated, especially among diabetic pedigree subjects when compared to non-diabetic controls (p= 0.003) and late-onset T2DM subjects (p = 0.014). However, no significant differences were observed between late-onset T2DM with or without diabetic pedigree and non-diabetic control subjects.

Conclusions: Our results suggest that 1) the NeuroD1-Ala45Thr variation may itself have an important role in susceptibility to or be in disequilibrium with early-onset T2DM in Chinese; 2) the Ala45Thr may affect the onset pattern of T2DM, i.e., early-onset but not late-onset T2DM in Chinese; and 3) onset-age stratified analysis may be useful to determine the association of NeuroD1-Ala45Thr variation with susceptibility to genetic heterogeneous T2DM in Chinese.

Keywords

Ala45Thr variation early-onset type 2 diabetes mellitus (T2DM) diabetic pedigree late-onset T2DM NeuroD1 gene 

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Copyright information

© Springer Science + Business Media, B.V. 2006

Authors and Affiliations

  • Limei Liu
    • 1
  • Weiping Jia
    • 1
  • Taishan Zheng
    • 1
  • Ming Li
    • 1
  • Huijuan Lu
    • 1
  • Kunsan Xiang
    • 1
  1. 1.Department of Endocrinology & Metabolism, Shanghai Diabetes InstituteShanghai Jiaotong University Affiliated Sixth People's HospitalShanghaiChina

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