Molecular and Cellular Biochemistry

, Volume 285, Issue 1–2, pp 1–15

Is there a specific role for the plasma membrane Ca2+-ATPase in the hepatocyte?

  • Blanca Delgado-Coello
  • Raquel Trejo
  • Jaime Mas-Oliva
Article

DOI: 10.1007/s11010-005-9060-z

Cite this article as:
Delgado-Coello, B., Trejo, R. & Mas-Oliva, J. Mol Cell Biochem (2006) 285: 1. doi:10.1007/s11010-005-9060-z

Abstract

The plasma membrane Ca2+-ATPase (PMCA) is responsible for the fine, long-term regulation of the cytoplasmic calcium concentration by extrusion of this cation from the cell. Although the general kinetic mechanisms for the action of both, well coordinated hydrolytic activity and calcium transport are reasonably understood in the majority of cell types, due to the complex physiologic and biochemical characteristics shown by the hepatocyte, the study of this enzyme in this cell type has become a real challenge. Here, we review the various molecular aspects known to date to be associated with liver PMCA activity, and outline the strategies to follow for establishing the role of this enzyme in the overall physiology of the hepatocyte. In this way, we first concentrate on the basic biochemical aspects of liver cell PMCA, and place an important emphasis on expression of its molecular forms to finally focus on the critical hormonal regulation of the enzyme. Although these complex aspects have been studied mainly under normal conditions, the significance of PMCA in the calcium homeostasis of an abnormal liver cell is also reviewed. (Mol Cell Biochem xxx: 1–15, 2005)

Key words

PMCA Ca2+ homeostasis hepatocyte hormone regulation 

Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Blanca Delgado-Coello
    • 1
  • Raquel Trejo
    • 1
  • Jaime Mas-Oliva
    • 1
  1. 1.Instituto de Fisiología CelularUniversidad Nacional Autónoma de México. MéxicoMéxicoD.F. México
  2. 2.Instituto de Fisiología CelularUNAM, Ciudad Universitaria, Apdo.04510 MéxicoD.F., México

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