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Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age

  • John E. Krzeczkowski
  • Amanda Lau
  • Jennifer Fitzpatrick
  • Sukhpreet Tamana
  • Lisa Smithson
  • Russell de Souza
  • Anita L. Kozyrskyj
  • Diana Lefebvre
  • Allan B. Becker
  • Padmaja Subbarao
  • Stuart E. Turvey
  • Jacqueline Pei
  • Louis A. Schmidt
  • Malcolm R. Sears
  • Ryan J. Van Lieshout
  • Piush J. MandhaneEmail author
  • the CHILD Study Investigators
Article
  • 75 Downloads

Abstract

Objectives Prenatal maternal metabolic problems such as pre-pregnancy adiposity, excess gestational weight gain, and gestational diabetes mellitus (GDM) are associated with an increased risk of psychopathology in offspring. We examined whether these exposures were linked to symptoms of emotional and behavioral problems in offspring at 2 years of age, or if associations were due to confounding variables. Methods Data from 815 mother–child pairs enrolled at the Edmonton site of the Canadian Healthy Infant Longitudinal Development cohort were used to examine associations between gestational metabolic complications and scores on the externalizing and internalizing scales of the Child Behavior Checklist (CBCL-1½ to 5) at age two. Associations between maternal metabolic complications and offspring psychopathology were assessed before and after adjustment for gestational diet, socioeconomic status (SES), postpartum depression (PPD), prenatal smoking and breastfeeding. Results Pre-pregnancy body mass index and GDM, but not gestational weight gain, predicted more offspring externalizing and internalizing problems. However, after adjustment for confounding variables, these associations were no longer statistically significant. Post-hoc analyses revealed that gestational diet accounted for unique variance in both externalizing (semi-partial rdiet = − 0.20, p < 0.001) and internalizing (semi-partial rdiet = − 0.16, p = 0.01) problems. PPD and SES also accounted for a similar amount of variance for both externalizing (semi-partial rPPD = 0.17, p < 0.001; rses = − 0.11, p = 0.03) and internalizing problems (semi-partial rPPD = 0.21, p < 0.001; rses = − 0.14, p = 0.004). Conclusions for Practice Since the confounding effect of gestational diet persisted after adjustment for, and was similar in magnitude to, SES and PPD, future research should consider the impact of unhealthy prenatal diets on offspring neurodevelopment.

Keywords

Child Behavior Checklist Gestational diabetes mellitus Obesity Prenatal nutrition Prenatal programming Preschool 

Notes

Acknowledgements

CHILD Study investigators contributors: Subbarao P (Director), The Hospital for Sick Children; Turvey SE, University of British Columbia (co-Director); Anand SS, McMaster University; Azad M, University of Manitoba; Becker AB, University of Manitoba; Befus AD, University of Alberta; Brauer M, University of British Columbia; Brook JR, University of Toronto; Chen E, Northwestern University, Chicago; Cyr M, McMaster University; Daley D, University of British Columbia; Dell S, Sick Children’s Hospital; Denburg JA, McMaster University; Duan Q, Queen’s University; Eiwegger T, The Hospital for Sick Children; Grasemann H, Sick Children’s Hospital; HayGlass K, University of Manitoba; Hegele R, Sick Children’s Hospital; Holness DL, University of Toronto; Hystad, Perry, Oregon State University; Kobor MS, University of British Columbia; Kollman TR, University of British Columbia; Kozyrskyj AL, University of Alberta; Laprise C, Université du Québec à Chicoutimi; Lou WYW, University of Toronto; Macri J, McMaster University; Mandhane PM, University of Alberta; Miller G, Northwestern University, Chicago; Moraes T, Sick Children’s Hospital; Paré PD, University of British Columbia; Ramsey C, University of Manitoba; Ratjen F, Sick Children’s Hospital; Sandford A, University of British Columbia; Scott JA, University of Toronto; Scott J, University of Toronto; Sears MR, (Founding Director), McMaster University; Silverman F, University of Toronto; Simons E, University of Manitoba; Takaro T, Simon Fraser University; Tebbutt S, University of British Columbia; To T, Sick Children’s Hospital;

Funding

This study was supported by Canadian Institute for Health Research (CIHR), AllerGen Network of Centers of Excellence, the Women and Children’s Health Research Institute (WCHRI), and PolicyWise.

Compliance with Ethical Standards

Conflict of interest

JEK is funded by the Vanier Graduate Scholarship Program. The remaining authors have no conflicts of interest relevant to this article to disclose. The individuals acknowledged have no conflicts of interest relevant to this article to disclose.

Supplementary material

10995_2018_2691_MOESM1_ESM.pdf (127 kb)
Supplementary material 1 (PDF 127 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • John E. Krzeczkowski
    • 1
  • Amanda Lau
    • 2
  • Jennifer Fitzpatrick
    • 2
  • Sukhpreet Tamana
    • 2
  • Lisa Smithson
    • 2
  • Russell de Souza
    • 3
  • Anita L. Kozyrskyj
    • 2
  • Diana Lefebvre
    • 4
  • Allan B. Becker
    • 5
  • Padmaja Subbarao
    • 6
  • Stuart E. Turvey
    • 7
  • Jacqueline Pei
    • 8
  • Louis A. Schmidt
    • 9
  • Malcolm R. Sears
    • 4
  • Ryan J. Van Lieshout
    • 9
  • Piush J. Mandhane
    • 2
    • 10
    Email author
  • the CHILD Study Investigators
  1. 1.Neuroscience Graduate ProgramMcMaster UniversityHamiltonCanada
  2. 2.Department of PediatricsUniversity of AlbertaEdmontonCanada
  3. 3.Department of Clinical Epidemiology and BiostatisticsMcMaster UniversityHamiltonCanada
  4. 4.Department of MedicineMcMaster UniversityHamiltonCanada
  5. 5.Manitoba Institute of Child HealthUniversity of ManitobaWinnipegCanada
  6. 6.Department of PediatricsUniversity of TorontoTorontoCanada
  7. 7.Department of PediatricsUniversity of British ColumbiaVancouverCanada
  8. 8.Department of Educational PsychologyUniversity of AlbertaEdmontonCanada
  9. 9.Department of Psychiatry and Behavioural NeurosciencesMcMaster UniversityHamiltonCanada
  10. 10.Department of Pediatrics, 4-590 Edmonton Clinic Health Academy (ECHA)University of AlbertaEdmontonCanada

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