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Maternal and Child Health Journal

, Volume 21, Issue 8, pp 1662–1668 | Cite as

Infant Adiposity is Independently Associated with a Maternal High Fat Diet but not Related to Niacin Intake: The Healthy Start Study

  • Allison L. B. Shapiro
  • Brandy M. Ringham
  • Deborah H. Glueck
  • Jill M. Norris
  • Linda A. Barbour
  • Jacob E. Friedman
  • Dana Dabelea
Article

Abstract

Objectives Over-nutrition during pregnancy resulting from maternal obesity or an unhealthy diet can lead to excess infant adiposity at birth. Specific dietary macro- and micronutrients have been shown to increase fat cell development in both in-vitro and in-vivo models and may therefore link maternal diet to increased infant adiposity. We hypothesized that high maternal dietary niacin intake during pregnancy, especially in combination with a high-fat diet (HFD) would increase infant adiposity. Methods We included 1040 participants from a pre-birth cohort of mother-infant pairs. Maternal diet was assessed using multiple 24-hour dietary recalls. HFD was defined as ≥30% of calories from fat and ≥12% of fat calories from saturated fat. Neonatal body composition (% fat mass [%FM], fat mass [FM], fat-free mass [FFM]) was measured by PEAPOD. We used multivariate regression to assess the joint effect of maternal dietary niacin and maternal HFD on neonatal body composition. Results Dietary niacin was not associated with neonatal body composition, and maternal HFD did not modify this finding. However, maternal HFD was independently associated with %FM (β = 0.8 [0.1, 1.4]%, p < 0.01] and FM (β = 32.4 [6.7, 58.0] g, p < 0.01). Conclusions for Practice Our results suggest that a HFD during pregnancy may increase infant adiposity, therefore supporting the need for improved diet counseling of pregnant women at both the clinical and community levels.

Keywords

Dietary niacin High-fat diet Infant adiposity. 

Notes

Acknowledgements

We would like to sincerely thank Mrs. Mercedes Martinez, the Healthy Start Project Manager and the entire Healthy Start team for their hard work and dedication. We would also like to thank Becky De la Houssaye for her help and guidance with processing of the umbilical cord tissue and optimization of the SIRT1 assay. Further, we would like to thank Dr. Anne Starling for her thoughtful suggestions during manuscript revisions. The Healthy Start study is funded by the National Institute on Diabetes and Digestive and Kidney Diseases (R01 #DK076648). Dabelea is responsible for the final content of this manuscript.

Supplementary material

10995_2016_2258_MOESM1_ESM.docx (44 kb)
Supplementary material 1 (DOCX 44 KB)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Allison L. B. Shapiro
    • 1
  • Brandy M. Ringham
    • 2
  • Deborah H. Glueck
    • 2
  • Jill M. Norris
    • 1
  • Linda A. Barbour
    • 3
  • Jacob E. Friedman
    • 4
  • Dana Dabelea
    • 1
  1. 1.Department of Epidemiology, Colorado School of Public Health (CSPH)University of Colorado Anschutz Medical CampusDenverUSA
  2. 2.Department of Biostatistics, CSPHUniversity of Colorado Anschutz Medical CampusDenverUSA
  3. 3.Departments of Medicine and Obstetrics and Gynecology, School of MedicineUniversity of ColoradoDenverUSA
  4. 4.Departments of Pediatrics and Biochemistry & Molecular Genetics, School of MedicineUniversity of ColoradoDenverUSA

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