Maternal and Child Health Journal

, Volume 19, Issue 12, pp 2605–2614 | Cite as

Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants

  • Claire D. Coles
  • Julie A. Kable
  • Carl L. Keen
  • Kenneth Lyons Jones
  • Wladimir Wertelecki
  • Irina V. Granovska
  • Alla O. Pashtepa
  • Christina D. Chambers
  • the CIFASD
Article

Abstract

Objectives

Fetal alcohol spectrum disorders are more common in disadvantaged populations. Environmental factors, like suboptimal nutrition, may potentiate the developmental effects of prenatal alcohol exposure. To evaluate the impact of micronutrients, including choline, on reduction of effects of exposure, we examined timing and dose of alcohol and effects of nutritional supplementation at two OMNI-Net sites in Western Ukraine that included high and low risk individuals.

Methods

Alcohol-using and nondrinking women were randomized to one of three multivitamin/mineral supplement groups: none, multivitamins/minerals (MVM), and multivitamin/minerals plus choline. Children (N = 367) were tested at 6 months with the Bayley Scales of Infant Development (2nd ED) yielding standard scores for Mental Development Index (MDI), Psychomotor Development Index (PDI) and Behavior.

Results

Generalized linear modeling was used: (1) for factorial analysis of effects of alcohol group, multivitamin/minerals, and choline supplementation; and (2) to examine the relationship between amount and timing of alcohol (ounces of absolute alcohol/day [ozAA/day] peri-conception and on average in the second trimester) and MVM supplementation on developmental outcomes while controlling sex, social class, and smoking. MDI was significantly impacted by peri-conceptual alcohol dose (\(\upchi_{(1)}^{2} = 8.54\), p < .001) with more alcohol associated with lower scores and males more negatively affected than females (\(\upchi_{(3)}^{2} = 11.04\), p < .002). Micronutrient supplementation had a protective effect; those receiving supplements performed better (\(\upchi_{(1)}^{2} = 8.03\), p < .005). The PDI motor scores did not differ by group but were affected by peri-conceptual alcohol dose (\(\upchi_{(1)}^{2} = 4.17\), p < .04).

Conclusions for Practice

Multivitamin/mineral supplementation can reduce the negative impact of alcohol use during pregnancy on specific developmental outcomes.

Keywords

Prenatal alcohol exposure Fetal alcohol spectrum disorders Multivitamin supplement Choline Infant development 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Claire D. Coles
    • 1
    • 7
  • Julie A. Kable
    • 1
  • Carl L. Keen
    • 2
  • Kenneth Lyons Jones
    • 3
  • Wladimir Wertelecki
    • 3
    • 4
    • 5
    • 6
  • Irina V. Granovska
    • 5
  • Alla O. Pashtepa
    • 6
  • Christina D. Chambers
    • 3
  • the CIFASD
  1. 1.Departments of Psychiatry and PediatricsEmory University School of MedicineAtlantaUSA
  2. 2.Department of NutritionUniversity of California-DavisDavisUSA
  3. 3.Department of PediatricsUniversity of California, San DiegoLa JollaUSA
  4. 4.University of South AlabamaMobileUSA
  5. 5.OMNI-Net for Children International Charitable FundRivne Regional Medical Diagnostic CenterRivneUkraine
  6. 6.OMNI-Net for Children International Charitable FundKhmelnytsky Perinatal CenterKhmelnytskyUkraine
  7. 7.Department of Psychiatry and Behavioral SciencesEmory University School of MedicineAtlantaUSA

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