Breastfeeding Versus Formula-Feeding and Girls’ Pubertal Development
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To examine the association of breastfeeding or its duration with timing of girls’ pubertal onset, and the role of BMI as a mediator in these associations. A population of 1,237 socio-economically and ethnically diverse girls, ages 6–8 years, was recruited across three geographic locations (New York City, Cincinnati, and the San Francisco Bay Area) in a prospective study of predictors of pubertal maturation. Breastfeeding practices were assessed using self-administered questionnaire/interview with the primary caregiver. Girls were seen on at least annual basis to assess breast and pubic hair development. The association of breastfeeding with pubertal timing was estimated using parametric survival analysis while adjusting for body mass index, ethnicity, birth-weight, mother’s education, mother’s menarcheal age, and family income. Compared to formula fed girls, those who were mixed-fed or predominantly breastfed showed later onset of breast development [hazard ratios 0.90 (95 % CI 0.75, 1.09) and 0.74 (95 % CI 0.59, 0.94), respectively]. Duration of breastfeeding was also directly associated with age at onset of breast development (p trend = 0.008). Associations between breastfeeding and pubic hair onset were not significant. In stratified analysis, the association of breastfeeding and later breast onset was seen in Cincinnati girls only. The association between breast feeding and pubertal onset varied by study site. More research is needed about the environments within which breastfeeding takes place in order to better understand whether infant feeding practices are a potentially modifiable risk factor that may influence age at onset of breast development and subsequent risk for disease in adulthood.
KeywordsPuberty Puberty-early onset Breastfeeding Body mass index
This study was funded by U01ES012770, U01ES012771, U01ES012800, U01ES012801, U01ES019435, U01ES019453, U01ES019454, and U01ES019457 from the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI); P01ES009584 and P30ES006096 from NIEHS; and UL1RR024131, UL1RR029887 and UL1RR026314 from the National Center for Research Resources (NCRR). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, the NCI, the NCRR, the National Institutes of Health, or the California Department of Public Health. We also gratefully acknowledge support of the Avon Foundation for this research.
- 4.Kadlubar, F. F., Berkowitz, G. S., Delongchamp, R. R., et al. (2003). The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. Cancer Epidemiology, Biomarkers & Prevention, 12(4), 327–331.Google Scholar
- 10.Karaolis-Danckert, N., Buyken, A. E., Sonntag, A., & Kroke, A. (2009). Birth and early life influences on the timing of puberty onset: Results from the DONALD (DOrtmund Nutritional and Anthropometric Longitudinally Designed) Study. American Journal of Clinical Nutrition, 90(6), 1559–1565.CrossRefPubMedGoogle Scholar
- 14.Novotny, R., Daida, Y. G., Grove, J. S., Acharya, S., & Vogt, T. M. (2003). Formula feeding in infancy is associated with adolescent body fat and earlier menarche. Cellular and Molecular Biology (Noisy-le-grand), 49(8), 1289–1293.Google Scholar
- 20.Hiatt, R. A., Haslam, S. Z., & Osuch, J. (2009). The breast cancer and the environment research centers: Transdisciplinary research on the role of the environment in breast cancer etiology. Environmental Health Perspectives, 117, 1814–1822. doi: 10.1289/ehp.0800120.CrossRefPubMedCentralPubMedGoogle Scholar
- 23.Vital and Health Statistics. 2000 CDC growth charts for the United States: Methods and development. DHHS Publication No. (PHS) 2002–1696. Accessed on May 12, 2012, from www.cdc.gov/nchs/data/series/sr_11/sr11_246.pdf.
- 24.Kleinbaum, D. G., & Klein, M. (2005). Survival analysis: A self-learning text (2nd ed.). New York: Springer.Google Scholar
- 31.Centers for Disease Control & Prevention. Breastfeeding report card—United States, 2010. Accessed on May 12, 2012, from http://www.cdc.gov/breastfeeding/data/.