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Maternal and Child Health Journal

, Volume 18, Issue 7, pp 1721–1727 | Cite as

Similarities and Differences in the Epidemiology of Pyloric Stenosis and SIDS

  • Sarka LisonkovaEmail author
  • K. S. Joseph
Article

Abstract

Similar temporal declines in infantile hypertrophic pyloric stenosis (IHPS) and sudden infant death syndrome (SIDS) and other common features have led to hypotheses about a shared etiology. We carried out a population-based study to highlight similarities and differences between IHPS and SIDS. We used vital statistics and hospitalization data on all live births in Washington State, USA (1987–2009). Changes in IHPS and SIDS rates over time were quantified using rate ratios with 95 % confidence intervals (CI). The duration between birth and diagnosis of IHPS or SIDS was examined as a function of gestational age at birth. Logistic regression analysis was used to identify risk factors and quantify adjusted temporal trends (2000–2008). Although both IHPS and SIDS rates declined significantly between 1987 and 2008, the patterns and magnitude of the declines (40 and 74 %, respectively) were different. IHPS and SIDS shared risk factors such as maternal smoking and single parent status but other factors showed qualitatively or and quantitatively different associations. Primiparity was a risk factor for IHPS [odds ratio (OR) 1.24, 95 % CI 1.09–1.41], and a protective factor for SIDS (OR 0.44, 95 % CI 0.36–0.55), while male sex had a stronger association with IHPS (OR 4.51, 95 % CI 3.85–5.28 vs 1.36, 95 % CI 1.13–1.64). Both IHPS and SIDS showed significant inverse associations between gestational age at birth and chronologic age at diagnosis/death. IHPS and SIDS share some epidemiologic features and risk factors but other risk factors have qualitatively or quantitatively different effects and recent temporal trends in the two diseases are dissimilar.

Keywords

Infantile hypertrophic pyloric stenosis Trend Epidemiology Sudden infant death syndrome 

Abbreviations

IHPS

Infantile hypertrophic pyloric stenosis

CI

Confidence interval

SIDS

Sudden infant death syndrome

Notes

Acknowledgments

S.L. is supported by a post-doctoral fellowship award from the Michael Smith Foundation for Health Research (MSFHR) and Rare Disease Foundation, and K.S.J.’s work is supported by an award from the Child and Family Research Institute and a Chair award from the Canadian Institutes of Health Research.

Conflict of interest

The authors have no conflicts of interest to disclose.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Obstetrics and GynaecologyUniversity of British Columbia and the Children’s and Women’s Hospital and Health Centre of British ColumbiaVancouverCanada
  2. 2.School of Population and Public HealthUniversity of British ColumbiaVancouverCanada

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