Maternal and Child Health Journal

, Volume 15, Issue 5, pp 670–676

Alcohol Consumption During Pregnancy and Risk of Placental Abruption and Placenta Previa

  • Muktar H. Aliyu
  • O’Neil Lynch
  • Philip N. Nana
  • Amina P. Alio
  • Roneé E. Wilson
  • Phillip J. Marty
  • Roger Zoorob
  • Hamisu M. Salihu
Article

Abstract

The purpose of this study was to examine the association between prenatal alcohol consumption and the occurrence of placental abruption and placenta previa in a population-based sample. We used linked birth data files to conduct a retrospective cohort study of singleton deliveries in the state of Missouri during the period 1989 through 2005 (n = 1,221,310). The main outcomes of interest were placenta previa, placental abruption and a composite outcome defined as the occurrence of either or both lesions. Multivariate logistic regression was used to generate adjusted odd ratios, with non-drinking mothers as the referent category. Women who consumed alcohol during pregnancy had a 33% greater likelihood for placental abruption during pregnancy (adjusted odds ratio (OR), 95% confidence interval (CI) = 1.33 [1.16–1.54]). No association was observed between prenatal alcohol use and the risk of placenta previa. Alcohol consumption in pregnancy was positively related to the occurrence of either or both placental conditions (adjusted OR [95% CI] = 1.29 [1.14–1.45]). Mothers who consumed alcohol during pregnancy were at elevated risk of experiencing placental abruption, but not placenta previa. Our findings underscore the need for screening and behavioral counseling interventions to combat alcohol use by pregnant women and women of childbearing age.

Keywords

Alcohol Placenta previa Placental abruption Population-based study 

References

  1. 1.
    Sokol, R. J., Delaney-Black, V., & Nordstrom, B. (2003). Fetal alcohol spectrum disorder. The journal of the American Medical Association, 290, 2996–2999.CrossRefGoogle Scholar
  2. 2.
    O’Leary, C. M., Nassar, N., Kurinczuk, J. J., & Bower, C. (2009). The effect of maternal alcohol consumption on fetal growth and preterm birth. An international journal of obstetrics and gynaecology, 116, 390–400.CrossRefGoogle Scholar
  3. 3.
    Aliyu, M. H., Wilson, R. E., Zoorob, R., Chakrabarty, S., Alio, A. P., Kirby, R. S., et al. (2008). Alcohol consumption during pregnancy and the risk of early stillbirth among singletons. Alcohol, 42, 369–374.PubMedCrossRefGoogle Scholar
  4. 4.
    Gundogan, F., Elwood, G., Longato, L., Tong, M., Feijoo, A., Carlson, R. I., et al. (2008). Impaired placentation in fetal alcohol syndrome. Placenta, 29, 148–157.PubMedCrossRefGoogle Scholar
  5. 5.
    Ananth, C. V., & Wilcox, A. J. (2001). Placental abruption and perinatal mortality in the United States. American Journal of Epidemiology, 153, 332–337.PubMedCrossRefGoogle Scholar
  6. 6.
    Rasmussen, S., Irgens, L. M., & Dalaker, K. (2000). Outcome of pregnancies subsequent to placental abruption: a risk assessment. Acta Obstetricia et Gynecologica Scandinavica, 79, 496–501.PubMedCrossRefGoogle Scholar
  7. 7.
    Salihu, H. M., Bekan, B., Aliyu, M. H., Rouse, D. J., Kirby, R. S., & Alexander, G. R. (2005). Perinatal mortality associated with abruptio placenta in singletons and multiples. American Journal of Obstetrics and Gynecology, 193, 198–203.PubMedCrossRefGoogle Scholar
  8. 8.
    Ananth, C. V., Smulian, J. C., Demissie, K., Vintzileos, A. M., & Knuppel, R. A. (2001). Placental abruption among singleton and twin births in the United States: Risk factor profiles. American Journal of Epidemiology, 153, 771–778.PubMedCrossRefGoogle Scholar
  9. 9.
    Ananth, C. V., Demissie, K., Smulian, J. C., & Vintzileos, A. M. (2001). Relationship among placenta previa, fetal growth restriction, and preterm delivery: A population-based study. Obstetrics and Gynecology, 98, 299–306.PubMedCrossRefGoogle Scholar
  10. 10.
    Salihu, H. M., Li, Q., Rouse, D. J., & Alexander, G. R. (2003). Placenta previa: neonatal death after live births in the United States. American Journal of Obstetrics and Gynecology, 188, 1305–1309.PubMedCrossRefGoogle Scholar
  11. 11.
    Tikkanen, M., Nuutila, M., Hiilesmaa, V., Paavonen, J., & Ylikorkala, O. (2006). Clinical presentation and risk factors of placental abruption. Acta Obstetricia et Gynecologica Scandinavica, 85, 700–705.PubMedCrossRefGoogle Scholar
  12. 12.
    Marbury, M. C., Linn, S., Monson, R., Schoenbaum, S., Stubblefield, P. G., & Ryan, K. J. (1983). The association of alcohol consumption with outcome of pregnancy. American Journal of Public Health, 73, 1165–1168.PubMedCrossRefGoogle Scholar
  13. 13.
    Halmesmäki, E. (1988). Alcohol counselling of 85 pregnant problem drinkers: Effect on drinking and fetal outcome. British Journal of Obstetrics and Gynaecology, 95, 243–247.PubMedCrossRefGoogle Scholar
  14. 14.
    Yang, Q., Wen, S. W., Phillips, K., Oppenheimer, L., Black, D., & Walker, M. C. (2009). Comparison of maternal risk factors between placental abruption and placenta previa. American Journal of Perinatology, 26, 279–286.PubMedCrossRefGoogle Scholar
  15. 15.
    Kramer, M. S., Usher, R. H., Pollack, R., Boyd, M., & Usher, S. (1997). Etiologic determinants of abruptio placentae. Obstetrics and Gynecology, 89, 221–226.PubMedCrossRefGoogle Scholar
  16. 16.
    Ananth, C. V., Demissie, K., Smulian, J. C., & Vintzileos, A. M. (2003). Placenta previa in singleton and twin births in the United States, 1989 through 1998: A comparison of risk factor profiles and associated conditions. American Journal of Obstetrics and Gynecology, 188, 275–281.PubMedCrossRefGoogle Scholar
  17. 17.
    Rasmussen, S., Albrechtsen, S., & Dalaker, K. (2000). Obstetric history and the risk of placenta previa. Acta Obstetricia et Gynecologica Scandinavica, 79, 502–507.PubMedCrossRefGoogle Scholar
  18. 18.
    Iyasu, S., Saftlas, A. K., Rowley, D. L., Koonin, L. M., Lawson, H. W., & Atrash, H. K. (1993). The epidemiology of placenta previa in the United States, 1979 through 1987. American Journal of Obstetrics and Gynecology, 168, 1424–1429.PubMedGoogle Scholar
  19. 19.
    Sheiner, E., Shoham-Vardi, I., Hallak, M., Hershkowitz, R., Katz, M., & Mazor, M. (2001). Placenta previa: Obstetric risk factors and pregnancy outcome. The Journal of maternal-fetal medicine, 10, 414–419.PubMedGoogle Scholar
  20. 20.
    Martin, J., Curtin, S., Saulnier, M., & Mousavi, J. (2003). Development of the matched multiple birth file. 1995–1998 matched multiple birth dataset. NCHS CD-ROM series 21, no. 13a. Hyattsville, MD: National Center for Health Statistics.Google Scholar
  21. 21.
    Kensmodel, U., Wisborg, K., Olsen, S. F., Henriksen, T. B., & Secher, N. J. (2002). Moderate alcohol intake during pregnancy and risk of stillbirth and death in the first year of life. American Journal of Epidemiology, 155, 305–312.CrossRefGoogle Scholar
  22. 22.
    Herman, A. A., McCarthy, B. J., Bakewell, J. M., et al. (1997). Data linkage methods used in maternally-linked birth and infant death surveillance data sets from the United States (Georgia, Missouri, Utah and Washington State), Israel, Norway, Scotland and Western Australia. Paediatric and Perinatal Epidemiology, 11, 5–22.PubMedCrossRefGoogle Scholar
  23. 23.
    Aliyu, M. H., Wilson, R. E., Zoorob, R., et al. (2009). Prenatal alcohol consumption and fetal growth restriction: potentiation effect by concomitant smoking. Nicotine & Tobacco Research, 11, 36–43.CrossRefGoogle Scholar
  24. 24.
    Alexander, G. R., Himes, J. H., Kaufman, R. B., Mor, J., & Kogan, M. (1996). A United States national reference for fetal growth. Obstetrics and Gynecology, 87, 163–168.PubMedCrossRefGoogle Scholar
  25. 25.
    Taffel, S., Johnson, D., & Heuser, R. (1982). A method of imputing length of gestation on birth certificates. Vital and Health Statistics. Series 2, Data Evaluation and Methods Research, 93, 1–11.PubMedGoogle Scholar
  26. 26.
    Alexander, G. R., & Cornely, D. A. (1987). Prenatal care utilization: Its measurement and relationship to pregnancy outcome. American Journal of Preventive Medicine, 3, 243–253.PubMedGoogle Scholar
  27. 27.
    Alexander, G. R., & Kotelchuck, M. (1996). Quantifying the adequacy of prenatal care: A comparison of indices. Public Health Reports, 111(5), 408–418.PubMedGoogle Scholar
  28. 28.
    Clayton, D., & Hills, M. (1993). Statistical models in epidemiology. Oxford: Oxford University Press.Google Scholar
  29. 29.
    Ananth, C. V., Smulian, J. C., & Vintzileos, A. M. (2003). The effect of placenta previa on neonatal mortality: A population-based study in the United States, 1989 through 1997. American Journal of Obstetrics and Gynecology, 188, 1299–1304.PubMedCrossRefGoogle Scholar
  30. 30.
    Naeye, R. L. (1989). Pregnancy hypertension, placental evidences of low uteroplacental blood flow, and spontaneous premature delivery. Human Pathology, 20, 441–444.PubMedCrossRefGoogle Scholar
  31. 31.
    Ylikorkala, O., Halmesmäki, E., & Viinikka, L. (1988). Urinary prostacyclin and thromboxane metabolites in drinking pregnant women and in their infants: Relations to the fetal alcohol effects. Obstetrics and Gynecology, 71, 61–66.PubMedGoogle Scholar
  32. 32.
    Jones, P. J., Leichter, J., & Lee, M. (1981). Placental blood flow in rats fed alcohol before and during gestation. Life Sciences, 29, 1153–1159.PubMedCrossRefGoogle Scholar
  33. 33.
    Little, R. E., Mandell, W., & Schultz, F. A. (1977). Consequences of retrospective measurement of alcohol consumption. Journal of studies on alcohol, 38, 1777–1780.PubMedGoogle Scholar
  34. 34.
    Jacobson, S. W., Chiodo, L. M., Sokol, R. J., & Jacobson, J. L. (2002). Validity of maternal report of prenatal alcohol, cocaine, and smoking in relation to neurobehavioral outcome. Pediatrics, 109, 815–825.PubMedCrossRefGoogle Scholar
  35. 35.
    Greene, T., Ernhart, C. B., Martier, S., Sokol, R., & Ager, J. (1990). Prenatal alcohol exposure and language development. Alcoholism, Clinical and Experimental Research, 14, 937–945.PubMedCrossRefGoogle Scholar
  36. 36.
    da Costa Pereira, A., Olsen, J., & Ogston, S. (1993). Variability of self reported measures of alcohol consumption: implications for the association between drinking in pregnancy and birth weight. Journal of Epidemiology and Community Health, 47, 326–330.PubMedCrossRefGoogle Scholar
  37. 37.
    Verkerk, P. H., Buitendijk, S. E., & Verloove-Vanhorick, S. P. (1994). Differential misclassification of alcohol and cigarette consumption by pregnancy outcome. International Journal of Epidemiology, 23, 1218–1225.PubMedCrossRefGoogle Scholar
  38. 38.
    Morgenstern, H., & Thomas, D. (1993). Principles of study design in environmental epidemiology. Environmental Health Perspectives, 101, 23–38.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Muktar H. Aliyu
    • 1
  • O’Neil Lynch
    • 2
  • Philip N. Nana
    • 3
  • Amina P. Alio
    • 4
  • Roneé E. Wilson
    • 5
  • Phillip J. Marty
    • 6
  • Roger Zoorob
    • 7
  • Hamisu M. Salihu
    • 4
  1. 1.Department of Preventive MedicineInstitute for Global Health, Vanderbilt UniversityNashvilleUSA
  2. 2.Department of MathematicsMinnesota State University MoorheadMoorheadUSA
  3. 3.Department of Obstetrics and GynecologyUniversity of Yaounde 1YaoundeCameroon
  4. 4.Department of Family and Community Health, Center for Research and Evaluation, Lawton and Rhea Chiles Center, For Healthy Mothers and BabiesUniversity of South FloridaTampaUSA
  5. 5.Department of Epidemiology and BiostatisticsUniversity of South FloridaTampaUSA
  6. 6.The Chiles Center for Healthy Mothers and BabiesUniversity of South FloridaTampaUSA
  7. 7.Southeast Fetal Alcohol Research and Training CenterMeharry Medical CollegeNashvilleUSA

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