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Ethanol-Induced Gastric Injury: Microscopic Analysis of the Protective Effect of Frutalin

  • Ana Paula Vasconcellos Abdon
  • Renata Prado Vasconcelos
  • Carolina Araújo Castro
  • Marjorie Moreira Guedes
  • Adriana da Rocha Tomé
  • André Luiz Herzog Cardoso
  • Thiago de Melo Santiago
  • Luciana Magalhães Rebêlo
  • Renato de Azevedo Moreira
  • Ana Cristina de Oliveira Monteiro-Moreira
  • Adriana Rolim CamposEmail author
Article

Abstract

Obtained from breadfruit seeds (Artocarpus incisa), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastric mucosa of mice submitted to ethanol-induced gastric injury. The gastroprotective effect of frutalina was evaluated using a murine model of ethanol-induced gastric injury. Damage of the gastric mucosa was assessed morphologically by light, scanning electron and atomic force microscopy. Lymphocyte infiltration, necrosis, disruption of the mucosal structures and epithelial desquamation were observed in the control group. In the group pretreated with frutalina at 0.5 mg/kg, gastroprotection, reduced tissue damage and preserved submucosal and mucosal structures were observed. In conclusion, FTL displayed gastroprotective activity against ethanol-induced gastric injury, preventing the formation of gastric ulcer and reducing epithelial desquamation, glandular damage, mucosal necrosis and infiltration. The observed effects appear to be due to mechanisms previously described for frutalin.

Keywords

Artocarpus incisa Frutalin Gastroprotective Ethanol-induced gastric injury Microscopic analysis 

Notes

Acknowledgments

The authors would like to thank CNPq, Funcap and Fundação Edson Queiroz for financial support.

Conflict of interest

The authors report no conflicts of interest.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Ana Paula Vasconcellos Abdon
    • 1
  • Renata Prado Vasconcelos
    • 1
  • Carolina Araújo Castro
    • 1
  • Marjorie Moreira Guedes
    • 2
    • 5
  • Adriana da Rocha Tomé
    • 3
  • André Luiz Herzog Cardoso
    • 4
  • Thiago de Melo Santiago
    • 5
  • Luciana Magalhães Rebêlo
    • 5
  • Renato de Azevedo Moreira
    • 1
  • Ana Cristina de Oliveira Monteiro-Moreira
    • 1
  • Adriana Rolim Campos
    • 1
    Email author
  1. 1.RENORBIOUniversity of Fortaleza (UNIFOR)FortalezaBrazil
  2. 2.Department of Physiology and PharmacologyFederal University of Ceará (UFC)FortalezaBrazil
  3. 3.Veterinarian SchoolState University of Ceará (UECE)FortalezaBrazil
  4. 4.Science and Technology CenterState University of Ceará (UECE)FortalezaBrazil
  5. 5.Department of PhysicsFederal University of Ceará (UFC)FortalezaBrazil

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