Lifetime Data Analysis

, Volume 19, Issue 1, pp 19–32

Competing risks with missing covariates: effect of haplotypematch on hematopoietic cell transplant patients

  • Thomas H. Scheike
  • Martin J. Maiers
  • Vanderson Rocha
  • Mei-Jie Zhang
Article

Abstract

In this paper we consider a problem from hematopoietic cell transplant (HCT) studies where there is interest on assessing the effect of haplotype match for donor and patient on the cumulative incidence function for a right censored competing risks data. For the HCT study, donor’s and patient’s genotype are fully observed and matched but their haplotypes are missing. In this paper we describe how to deal with missing covariates of each individual for competing risks data. We suggest a procedure for estimating the cumulative incidence functions for a flexible class of regression models when there are missing data, and establish the large sample properties. Small sample properties are investigated using simulations in a setting that mimics the motivating haplotype matching problem. The proposed approach is then applied to the HCT study.

Keywords

Binomial modeling Bone marrow transplant Competing risks Haplotype effects Haplotype match Missing covariates Inverse-censoring probability weighting Nonparametric effects Non-proportionality Regression effects 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Thomas H. Scheike
    • 1
  • Martin J. Maiers
    • 2
  • Vanderson Rocha
    • 3
  • Mei-Jie Zhang
    • 4
  1. 1.Department of BiostatisticsUniversity of CopenhagenCopenhagenDenmark
  2. 2.National Marrow Donor ProgramMinneapolisUSA
  3. 3.Hematology Bone Marrow Transplant DepartmentHospital Saint-LouisParisFrance
  4. 4.Division of BiostatisticsMedical College of WisconsinMilwaukeeUSA

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