Lifetime Data Analysis

, Volume 17, Issue 2, pp 256–279

Linear regression analysis of survival data with missing censoring indicators

Article

Abstract

Linear regression analysis has been studied extensively in a random censorship setting, but typically all of the censoring indicators are assumed to be observed. In this paper, we develop synthetic data methods for estimating regression parameters in a linear model when some censoring indicators are missing. We define estimators based on regression calibration, imputation, and inverse probability weighting techniques, and we prove all three estimators are asymptotically normal. The finite-sample performance of each estimator is evaluated via simulation. We illustrate our methods by assessing the effects of sex and age on the time to non-ambulatory progression for patients in a brain cancer clinical trial.

Keywords

Asymptotic normality Censoring indicator Imputation Inverse probability weighting Least squares Missing at random Regression calibration 

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Copyright information

© US Government  2010

Authors and Affiliations

  1. 1.Department of Mathematics and StatisticsYunnan UniversityKunmingChina
  2. 2.Academy of Mathematics and Systems ScienceChinese Academy of ScienceBeijingChina
  3. 3.Biostatistics BranchNational Institute of Environmental Health Sciences, Research Triangle ParkNorth CarolinaUSA

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