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Landscape Ecology

, Volume 33, Issue 11, pp 1925–1938 | Cite as

Host functional connectivity and the spread potential of Lyme disease

  • Alexander G. WattsEmail author
  • Santiago Saura
  • Claire Jardine
  • Patrick Leighton
  • Lisa Werden
  • Marie-Josée Fortin
Research Article

Abstract

Context

In the ecology of Lyme disease emergence, it remains unclear to what extent spread of the tick vector (Ixodes scapularis) and the pathogen (Borrelia burgdorferi) are dependent upon the dispersal of vertebrate hosts in spatially heterogeneous landscapes. Yet, empirical measure of these complex ecologically driven spread processes present conceptual and methodological challenges despite important public health implications.

Objectives

To examine the relationship between landscape characteristics and tick-borne disease spread, we modeled the influence of landscape connectivity for a simplified vertebrate host community (white-footed mouse—Peromyscus leucopus, American robin—Turdus migratorius, white-tailed deer—Odocoileus virginianus) on the potential spread of the tick population compared to the pathogen in a spatially-structured landscape.

Methods

We parameterized a hybrid demographic-dispersal connectivity model by combining a series of reported host dispersal and tick burden estimates with empirically-measured tick abundance and pathogen prevalence sampled from a Lyme-endemic island landscape in Thousand Islands National Park (Ontario, Canada) and simulated several tick- and pathogen-spread scenarios.

Results

The extent of tick spread by mice [amount of reachable habitat (ARH) = 18.0%] is considerably similar to that of robins (ARH = 18.7%), while deer support the greatest tick spread extent (ARH = 82.0%). Infected mice carrying ticks support the highest pathogen spread (ARH = 19.8%). Short-distance pathogen spread and long-distance tick spread were facilitated by intermediate stepping stone habitat fragments.

Conclusions

We provide evidence that host functional connectivity mediates tick spread differently than pathogen spread, and depends strongly on landscape configuration. Our study therefore emphasizes the importance of landscape spatial heterogeneity on the ecological processes that influence regional tick-borne disease spread.

Keywords

Network theory Tick-borne disease Stepping stones Disease ecology Host–parasite interactions Landscape configuration 

Notes

Acknowledgements

Field and laboratory work was conducted as part of another project (Werden et al. 2014) and was supported by Emily Gonzales at Thousand Islands National Park (TINP); Jeff Bowman at the Ontario Ministry of Natural Resources and Forestry (OMNRF); Ian K. Barker at the Canadian Wildlife Health Cooperative (CWHC) and Robbin Lindsay at the Public Health Agency of Canada. We thank the numerous students and staff from the OMNRF, CWHC, PHAC, and TINP who contributed to field data collection and lab work. We thank the associate editor and reviewers for their constructive comments.

Funding

M-JF was supported by NSERC Discovery Grant #5134. SS was supported by grant AGL2012-31099 from the Spanish Ministry of Economy and Competitiveness. AGW was partially supported by the University of Toronto, Department of Ecology & Evolution, and by Ontario Graduate Scholarships.

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

Supplementary material

10980_2018_715_MOESM1_ESM.docx (1.9 mb)
Supplementary material 1 (DOCX 1983 kb)

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Li Ka Shing Knowledge InstituteSt. Michael’s HospitalTorontoCanada
  2. 2.Department of Ecology & Evolutionary BiologyUniversity of TorontoTorontoCanada
  3. 3.Departamento de Sistemas y Recursos NaturalesUniversidad Politécnica de MadridMadridSpain
  4. 4.European Commission, Joint Research Centre (JRC), Directorate D - Sustainable ResourcesIspraItaly
  5. 5.Department of Pathobiology and Canadian Wildlife Health CooperativeUniversity of GuelphGuelphCanada
  6. 6.Department of Pathology and Microbiology, Faculty of Veterinary MedicineUniversité de MontréalSaint-HyacintheCanada
  7. 7.Thousand Islands National ParkMallorytownCanada

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