The role of satellite and other functional cell types in muscle repair and regeneration
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Skeletal muscles play essential roles in physiological processes, including motor function, energy hemostasis, and respiration. Skeletal muscles also have the capacity to regenerate after injury. Regeneration of skeletal muscle is an extremely complex biological process, which involves multiple cell types. Skeletal muscle stem cells (also known as satellite cells; SCs) are crucial for the development, growth, maintenance and repair of the skeletal muscle. Cell fates and function have been extensively studied in the context of skeletal muscle regeneration. In addition to SCs, other cell types, such as fibro-adipogenic precursors (FAPs), endothelial cells, fibroblasts, pericytes and certain immune cells, play important regulatory roles during skeletal muscle regeneration. In this review, we summarize and discuss the current research progress on the different cell types and their respective functions in skeletal muscle regeneration and repair.
KeywordsMuscle regeneration Satellite cell Fibro-adipogenic precursor Endothelial cell Immune cell Lymphocyte
The project was partially supported by the National Natural Science Foundation of China (Grant No. 31672427) to TZS.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- Aranguren XL, Pelacho B, Peñuelas Abizanda G, Uriz M, Ecay M, Collantaes M, Araña M, Beerens M, Coppiello G, Prieto I, Perez-Ilzarbe M, Andreu EJ, Luttun A, Prósper F (2011) MAPC transplantation confers a more durable benefit than AC133+ cell transplantation in severe hind limb ischemia. Cell Transplant 20(2):259–269CrossRefGoogle Scholar
- Blotnick S, Peoples GE, Freeman MR, Eberlein TJ, Klagsbrun M (1994) T-lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth-factor and basic fibroblast growth-factor, mitogens for vascular cells and fibroblasts—differential production and release by Cd4+ And Cd8+ T-cells. Proc Natl Acad Sci USA 91:2890–2894CrossRefGoogle Scholar
- De Angelis L, Berghella L, Coletta M, Lattanzi L, Zanchi M, Cusella-De Angelis MG, Ponzetto C, Cossu G (1999) Skeletal myogenic progenitors originating from embryonic dorsal aorta coexpress endothelial and myogenic markers and contribute to postnatal muscle growth and regeneration. J Cell Biol 147(4):869–878CrossRefGoogle Scholar
- Filigheddu N, Gnocchi VF, Coscia M, Cappelli M, Porporato PE, Taulli R, Traini S, Baldanzi G, Chianale F, Cutrupi S, Arnoletti E, Ghe C, Fubini A, Surico N, Sinigaglia F, Ponzetto C, Muccioli G, Crepaldi T, Graziani A (2007) Ghrelin and des-acyl ghrelin promote differentiation and fusion of C2C12 skeletal muscle cells. Mol Biol Cell 18:986–994CrossRefGoogle Scholar
- Fontenot JD, Gavin MA, Rudensky AY (2017) Foxp3 programs the development and function of CD4(+)CD25(+) regulatory T cells. J Immunol 198:986–992Google Scholar
- Latroche C, Weiss-Gayet M, Muller L, Gitiaux C, Leblanc P, Liot S, Ben-Larbi S, Abou-Khalil R, Verger N, Bardot P, Magnan M, Chretien F, Mounier R, Germain S, Chazaud B (2017) Coupling between myogenesis and angiogenesis during skeletal muscle regeneration is stimulated by restorative macrophages. Stem Cell Reports 9:2018–2033CrossRefGoogle Scholar
- Mozzetta C, Consalvi S, Saccone V, Tierney M, Diamantini A, Mitchell KJ, Marazzi G, Borsellino G, Battistini L, Sassoon D, Sacco A, Puri PL (2013) Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. Embo Mol Med 5:626–639CrossRefGoogle Scholar
- Torrente Y, Belicchi M, Sampaolesi M, Pisati F, Meregalli M, D'Antona G, Tonlorenzi R, Porretti L, Gavina M, Mamchaoui K, Pellegrino MA, Furling D, Mouly V, Butler-Browne GS, Bottinelli R, Cossu G, Bresolin N (2004) Human circulating AC133+ stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle. J Clin Invest 114(2):182–195CrossRefGoogle Scholar