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Insight on spectral, thermal and biological behaviour of some Cu(II) complexes with saturated pentaazamacrocyclic ligands bearing amino acid residues

  • Elena Pătraşcu
  • Mihaela Badea
  • Nataša Čelan Korošin
  • Romana Cerc Korošec
  • Lavinia L. Ruţă
  • Ileana C. Farcaşanu
  • Maria Nicoleta Grecu
  • Gérald Guillaumet
  • Rodica OlarEmail author
Article
  • 15 Downloads

Abstract

A novel series of Cu(II) complexes with formula M(HLn)(ClO4)2·mH2O [HLn: 13-membered pentaazamacrocyclic ligand resulted from condensation of N,N′-bis(2-aminoethyl)ethane-1,2-diamine, l-tyrosine (HL1)/l-tryptophan (HL2)/l-phenylalanine (HL3) and formaldehyde] were synthesized by one-pot method. Techniques such as ESI–MS, IR, UV–Vis and EPR spectroscopy provided data characterizing the complexes as mononuclear species. The course of thermal decomposition was followed using TG/DSC–MS analysis in air atmosphere. The TG curves showed a gradual decomposition in several stages that comprise dehydration, decomposition of perchlorate ions as well as fragmentation and oxidative degradation of the organic part. The intermediates formed after first stage of water elimination are stable on 40, 15 and 80 °C interval for complexes (1), (2) and (3), respectively. The compounds were tested on the eukaryotic unicellular organism Saccharomyces cerevisiae, showing variable actions in terms of toxicity, cellular uptake and capacity to alleviate growth defects associated with Cu, Zn-superoxide dismutase (SOD1) depletion.

Keywords

Formaldehyde Amino acid Pentaazamacrocyclic ligand SOD1 Thermal stability Yeast 

Notes

Acknowledgements

Slovenian authors would like to thank the Slovenian Research Agency—Slovenia (ARRS) for foundation by Programme P1-0134.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2020

Authors and Affiliations

  • Elena Pătraşcu
    • 1
  • Mihaela Badea
    • 1
  • Nataša Čelan Korošin
    • 2
  • Romana Cerc Korošec
    • 2
  • Lavinia L. Ruţă
    • 3
  • Ileana C. Farcaşanu
    • 3
  • Maria Nicoleta Grecu
    • 4
  • Gérald Guillaumet
    • 5
  • Rodica Olar
    • 1
    Email author
  1. 1.Department of Inorganic Chemistry, Faculty of ChemistryUniversity of BucharestBucharestRomania
  2. 2.Faculty of Chemistry and Chemical TechnologyUniversity of LjubljanaLjubljanaSlovenia
  3. 3.Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of ChemistryUniversity of BucharestBucharestRomania
  4. 4.National Institute of Materials PhysicsMăgureleRomania
  5. 5.Institut de Chimie Organique et Analytique (ICOA), Université d’Orléans, UMR-CNRS 7311Orléans Cedex 2France

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