Journal of Thermal Analysis and Calorimetry

, Volume 138, Issue 5, pp 3559–3569 | Cite as

Modified release microcapsules loaded with red propolis extract obtained by spray-dryer technique

Phytochemical, thermal and physicochemical characterizations
  • Ticiano G. do NascimentoEmail author
  • Gerson D. P. Redondo
  • Carla T. de Araújo Abreu
  • Valdemir C. Silva
  • Giselda M. Lira
  • Luciano A. Meireles Grillo
  • Marta Maria da Conceição
  • Johnnatan D. Freitas
  • Jonas S. Souza
  • João X. Araújo Júnior
  • Irinaldo D. Basílio-Júnior


Biopolymers are currently one of the most interesting materials applied in the medical and pharmaceutical fields. The objective of this work was to develop the modified release microcapsules loaded with red propolis extract (RPE) using a spray-dryer technique. In addition, this manuscript characterizes this red propolis microcapsules using phytochemicals, thermal, physicochemical and dissolution test. The RPE was incorporated in the biopolymer solution, and then submitted to spray-dryer technique to obtain modified release microcapsules loaded with RPE; then, they were submitted to different physicochemical characterization technique through SEM analysis, FTIR, thermal analysis (TG and DSC), dissolution test and phytochemical assays. The red propolis microcapsules presented spherical morphology with particle size between 2.5 and 35 μm, when analyzed by SEM technique. The thermal analysis showed that the coating material decreases the thermo-oxidative degradation of the RPE in the microcapsules and according to the calorimetric curves (DSC) and infrared spectra the microencapsulation of the red propolis extract was obtained. The quantification of the bioactive compounds showed high amounts of total phenols (98.3%) and total flavonoids (92.9%) contents, and it was possible determinate the encapsulation degree in microcapsules. The red propolis microcapsules present high antioxidant capacity (90.6%) in sequestering the free radical DPPH˙. The dissolution tests demonstrate slow flavonoids release (between 70 and 100%) from the microcapsules and have proven to be modified release microcapsules during 12 h experiments. The red propolis microcapsules can be applied in pharmaceutical and nutraceutical areas due to modified release property, antioxidant and antibacterial activities.


Red propolis Biopolymers Spray drying Microencapsulation Modified release 



The authors thank to the CAPES and CNPq for its financial support (Grant No: 446630/2014-4) according to the financial aid to the researchers 14/2014-Universal/MCT/CNPq. The authors thank to the FAPEAL for its financial support PPSUS 2016 (Grant No: 600 30 000431/2017) and Edital PPG´s No 14/2016 (Grant No: 60030 000852/2016) according to the financial aid to the researchers 14/2014-Universal/MCT/CNPq The authors thank to FINEP for its financial support (CT-INFRA) in acquisition of some equipment’s and laboratorial facilities. The authors also want to thank to the Pharmaceutical Analysis Laboratory (LAFA) in the persons of Felipe Jardell Leão for the technical support at the dissolution test and dissolution profile and Johnnatan Freitas for the support in the SEM analysis at the Federal Institute of Alagoas.

Supplementary material

10973_2019_8287_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 14 kb)


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2019

Authors and Affiliations

  • Ticiano G. do Nascimento
    • 1
    • 2
    Email author
  • Gerson D. P. Redondo
    • 1
  • Carla T. de Araújo Abreu
    • 2
  • Valdemir C. Silva
    • 1
  • Giselda M. Lira
    • 2
  • Luciano A. Meireles Grillo
    • 1
  • Marta Maria da Conceição
    • 3
  • Johnnatan D. Freitas
    • 4
  • Jonas S. Souza
    • 4
  • João X. Araújo Júnior
    • 1
  • Irinaldo D. Basílio-Júnior
    • 1
    • 2
  1. 1.Laboratório de Tecnologia Farmacêutica e Laboratório de Análises Farmacêuticas e Alimentícias (LAFA), Programa de Pós-Graduação em Ciências Farmacêuticas, Escola de Enfermagem e Farmácia (ESENFAR)Universidade Federal de Alagoas (UFAL)MaceióBrazil
  2. 2.Laboratório de Tecnologia de Secagem, Programa de Pós-Graduação em Nutrição, Faculdade de NutriçãoUniversidade Federal de Alagoas (UFAL)MaceióBrazil
  3. 3.Departamento de Tecnologia de Alimentos, Centro de TecnologiaUniversidade Federal da ParaíbaJoão PessoaBrazil
  4. 4.Departamento de QuímicaInstituto Federal de Alagoas (IFAL)MaceióBrazil

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