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Journal of Thermal Analysis and Calorimetry

, Volume 134, Issue 3, pp 1839–1850 | Cite as

Spectral, thermal and biological characterization of complexes with a Schiff base bearing triazole moiety as potential antimicrobial species

  • Larisa Calu
  • Mihaela Badea
  • Nataša Čelan Korošin
  • Mariana Carmen Chifiriuc
  • Coralia Bleotu
  • Nicolae Stanică
  • Luigi Silvestro
  • Martin Maurer
  • Rodica OlarEmail author
Article
  • 68 Downloads

Abstract

A novel series of complexes ML(ClO4)·nH2O (M: Co, Ni, Cu, Zn; HL: 2-[(E)-(1H-1,2,4-triazol-3-ylimino)methyl]phenol) have been synthesized and characterized as mononuclear species. The features of complexes have been assigned from microanalytical, FAB-MS, IR, UV–Vis-NIR, EPR and magnetic data. The IR spectra indicate the chelate behaviour of Schiff base and the perchlorate presence either as free ion or as ligand. Electronic and magnetic data are consistent with hexa-coordination of Co(II) and Ni(II) and penta-coordination for Cu(II) ions in complexes. The simultaneous TG-DSC/MS measurements evidenced processes as water (hydration or coordination) elimination, perchlorate decomposition as well as Schiff base both fragmentation and oxidative degradation. The in vitro screening of the antimicrobial behaviour on Gram-positive and Gram-negative bacteria, as well as on fungal strains, indicates a good activity for Cu(II) and Zn(II) complexes against both planktonic or adherent cells. Moreover, Cu(II) complex also exhibited a promising antiproliferative activity on HT 29 cell line.

Keywords

Complex Cytotoxicity Biofilm 1,2,4-Triazole Schiff base Thermal behaviour 

Notes

Acknowledgements

The authors thank researcher Gabriela Ionită from “Ilie Murgulescu” Physical Chemistry Institute of Romanian Academy for EPR measurements.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2018

Authors and Affiliations

  • Larisa Calu
    • 1
    • 2
  • Mihaela Badea
    • 1
  • Nataša Čelan Korošin
    • 3
  • Mariana Carmen Chifiriuc
    • 4
    • 5
  • Coralia Bleotu
    • 6
  • Nicolae Stanică
    • 7
  • Luigi Silvestro
    • 8
  • Martin Maurer
    • 8
  • Rodica Olar
    • 2
    Email author
  1. 1.Department of Inorganic Chemistry, Faculty of ChemistryUniversity of BucharestBucharestRomania
  2. 2.Cellular Dynamics and Flow Cytometry DepartmentNational Institute R&D for Biological SciencesBucharestRomania
  3. 3.Department of Inorganic Chemistry, Faculty of Chemistry and Chemical TechnologyUniversity of LjubljanaLjubljanaSlovenia
  4. 4.Department of Microbiology, Faculty of BiologyUniversity of BucharestBucharestRomania
  5. 5.Research Institute of the University of Bucharest, ICUBBucharestRomania
  6. 6.Stefan S. Nicolau Institute of VirologyBucharestRomania
  7. 7.“Ilie Murgulescu” Physical Chemistry InstituteRomanian AcademyBucharestRomania
  8. 8.3S-Pharmacological Consultation & Research GmbHHarpstedtGermany

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