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Journal of Thermal Analysis and Calorimetry

, Volume 134, Issue 3, pp 1923–1928 | Cite as

Quality standardization of herbal medicines of Spondias dulcis Parkinson using analytical and microbiological analysis

  • Felipe Hugo Alencar Fernandes
  • Fabio Boylan
  • Hérida Regina Nunes Salgado
Article

Abstract

The quality control is vital for the safety and efficacy of herbal medicines. However, the quality of standardization is most difficult because the studies do not cover this step. The objective of this study was quality standardization of herbal drugs of Spondias dulcis Parkinson. The leaves were dried and ground to a powder. The plant drug was evaluated by parameters of mean particle size (417.85 μm), apparent density (0.37 ± 0.01 g mL−1), moisture content (7.96 ± 0.35%), loss on drying (7.33 ± 0.09%), pH (3.90 ± 0.01), total ash (12.66 ± 0.23%), acid insoluble ash (3.22 ± 0.20%) and aqueous extractives (24.00 ± 3.28%). Phytochemical screening revealed the presence of flavonoids and tannins. Microbiological analysis presented a total count within the recommended limits and the absence of pathogenic microorganisms. The infrared spectroscopy (FTIR) and thermal analysis (TG/DTA) showed that physical and chemical processes occurred. The FTIR fingerprint has been characterized by characteristic peaks. The TG curves present six steps, and DTA curve presents three events. The results provide the scientific data for the proper identification and establishment of standards for future investigations and applications.

Keywords

Herbal drugs Thermoanalytical characterization Physicochemical characterization 

Abbreviations

DTA

Differential thermal analysis

DTG

Derivative thermogravimetry

EMB

Eosin methylene blue

FTIR

Infrared spectroscopy with Fourier transform

GC

Gas chromatography

HPLC

High-performance liquid chromatography

TG

Thermogravimetry

TLC

Thin-layer chromatography

TSI

Triple sugar and iron agar

XLD

Xylose lysine deoxycholate agar

Notes

Acknowledgements

The authors gratefully acknowledge Maria de Fátima Moretti for technical support.

Funding

This work was supported by PADC—FCFAr Unesp, CNPq and Capes Foundation.

Compliance with ethical standards

Conflict of interest

No potential conflict of interest was reported by the authors.

Human or animal rights

This article does not contain any studies with human or animal subjects.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2018

Authors and Affiliations

  1. 1.School of Pharmaceutical SciencesSão Paulo State UniversityAraraquaraBrazil
  2. 2.Faculdade de Ciências MédicasUNIFACISA – Centro UniversitárioCampina GrandeBrazil
  3. 3.School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences InstituteTrinity College DublinDublinIreland

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