Journal of Thermal Analysis and Calorimetry

, Volume 132, Issue 2, pp 1077–1088 | Cite as

Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes

  • Wilhan Donizete Gonçalves Nunes
  • André Luiz Carneiro Soares do Nascimento
  • Aniele Moura
  • Caroline Gaglieri
  • Gustavo Brunelli Vallim
  • Luiz Carlos Nascimento
  • Roni Antônio Mendes
  • Massao Ionashiro
  • Flávio Junior Caires
Article

Abstract

Coordination compounds of transition metals with norfloxacin (Nor) have potential to improve its effectiveness, as already discussed for some compounds found in the literature. The complexes in the solid state were prepared by precipitation of the respective metal cation (M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)) with a norfloxacin sodium salt solution. The thermal behavior under oxidative and pyrolysis conditions was investigated employing thermogravimetry and differential thermal analysis (TG/DTG–DTA) and evolved gas analysis (EGA/TG-FTIR), and the complexes were characterized by elemental analysis (EA), EDTA complexometric titration, infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). By these results, the minimum formula was established as [M(Nor)2(H2O)2nH2O, where n = 3 (Ni), 2.5 (Mn Co, Zn), or 2 (Cu). The evolved gases identified during thermal decomposition of Ni and Cu complexes were ethylene, CO2 and CO for Ni; CO2 and ethane for Cu. Also, antimicrobial activity of the complexes was evaluated by in vitro susceptibility test using the agar diffusion method, and the results were compared with the uncomplexed molecule. It was found that norfloxacin complexation modifies its antibacterial activity. The activity depends on the type of metal ion and microorganism; Mn(II), Co(II) and Zn(II) complexes significantly increased activity against the tested gram-negative bacteria.

Keywords

Norfloxacin Complexes Thermal behavior Antibacterial activity 

Notes

Acknowledgements

The authors thank FAPESP (Proc. 2017/14936-9), CNPq (Proc. 421469/2016-1) and CAPES Foundation (Brazil) for financial support and PhD Patricia Neves Mendes (UNIFAL-MG) for the aid in the statistical tests.

Supplementary material

10973_2018_7019_MOESM1_ESM.docx (24 kb)
Supplementary material 1 (DOCX 24 kb)

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2018
corrected publication February 2018

Authors and Affiliations

  • Wilhan Donizete Gonçalves Nunes
    • 1
  • André Luiz Carneiro Soares do Nascimento
    • 1
  • Aniele Moura
    • 1
  • Caroline Gaglieri
    • 2
  • Gustavo Brunelli Vallim
    • 3
  • Luiz Carlos Nascimento
    • 3
  • Roni Antônio Mendes
    • 4
  • Massao Ionashiro
    • 1
  • Flávio Junior Caires
    • 1
    • 2
  1. 1.Instituto de QuímicaUniversidade Estadual Paulista (UNESP)AraraquaraBrazil
  2. 2.Faculdade de CiênciasUniversidade Estadual Paulista (UNESP)BauruBrazil
  3. 3.Faculdade de Ciências FarmacêuticasUniversidade Federal de Alfenas (UNIFAL-MG)AlfenasBrazil
  4. 4.Instituto de Ciência e TecnologiaUniversidade Federal de Alfenas (UNIFAL-MG)Poços de CaldasBrazil

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