Magnesium aluminium silicate–gentamicin complex for drug delivery systems
- 278 Downloads
This paper presents the characteristics of magnesium aluminium silicate–gentamicin complexes for drug delivery systems. The work describes the results of studies on the successful introduction of gentamicin (an aminoglycoside antibiotic) into the interlayers of smectite clay and examines the possible use of intercalated smectite as a carrier for sustained drug release. Characterisation of magnesium aluminium silicate–gentamicin complexes was carried out by means of X-ray diffraction, Fourier transform infrared spectroscopy, thermal analysis and scanning electron microscopy with EDX analysis. The possibility of using the gentamicin intercalated smectite as a carrier for sustained release of the drug was investigated during in vitro study, in which the release rate of gentamicin from the smectite clay matrix was monitored based on absorption at 330 nm using a UV–Vis spectrometer and the kinetic of drug release was evaluated based on the zero-order, first-order, Higuchi and Korsmeyer–Peppas models. The results confirmed the efficiency of intercalation and indicate the potential for introducing gentamicin into the interlayer space of montmorillonite. Accordingly, the obtained material may thus be used as a drug carrier in modulated drug delivery systems.
KeywordsClays Gentamicin Drug release Intercalation Biomedical applications
This study was performed within the framework of funding for statutory activities of AGH University of Science and Technology in Cracow, Faculty of Materials Science and Ceramics (18.104.22.1687).
- 20.United States Pharmacopeial Convention. Content of gentamicin sulfate. Rockville, MD: United States Pharmacopeial Convention; 2011.Google Scholar
- 21.Clinical guideline for gentamicin prescribing and therapeutic drug monitoring. Royal Cornwall Hospitals NHS; 2014.Google Scholar
- 22.Hadjiioannou TP, Christian GD, Koupparis MA, Macheras PE. Quantitative calculations in pharmaceutical practice and research. New York: VCH Publishers Inc.; 1993.Google Scholar
- 30.Raussell-Colom JA, Serratosa JM. Reactions of clays with organic substances. In: Newman ACD, editor. Chemistry of clays and clay minerals. Mineralogical society monograph, vol. 6. Essex: Longman Scientific and Technical; 1987. p. 371–422.Google Scholar
- 35.Bailey SW, editor. Hydrous phyllosilicates (exclusive of micas). Reviews in mineralogy, vol. 19. Washington, DC: Mineralogical Society of America; 1988.Google Scholar
- 57.Patel HA, Somani RS, Bajaj HC, Jasra RV. Synthesis and characterization of organic bentonite using Gujarat and Rajasthan clays. Curr Sci. 2007;92:1004–9.Google Scholar