Journal of Thermal Analysis and Calorimetry

, Volume 127, Issue 1, pp 487–497 | Cite as

Insight on thermal behaviour of new complexes of Ni(II), Cu(II) and Zn(II) with a bismacrocyclic ligand developed as biologically active species

  • Mihaela Badea
  • Cristina Bucur
  • Mariana Carmen Chifiriuc
  • Coralia Bleotu
  • Maria-Nicoleta Grecu
  • Veronica Lazar
  • Dana Marinescu
  • Rodica Olar


A multi-component reaction involving metal ion, amines and formaldehyde has been used for a series of decaaza bismacrocyclic complexes M2L(CH3COO)4·nH2O [(1) M: Ni, n = 2.5; (2) M:Cu, n = 1; (3) M:Zn, n = 10; L:1,3-bis(N,N-1,3,6,9,12-pentaazacyclotridecane)-benzene] preparation. Elemental analyses, ESI-MS, IR, UV–Vis–NIR, NMR and EPR spectra, magnetic susceptibility at room temperature, molar conductivities, as well as thermogravimetric analysis, provided data concerning complexes features. The macrocyclic ligand behaves as bischelate, resulting in either a square planar or an octahedral stereochemistry. The in vitro screening of the antimicrobial activity was performed against both reference and clinical isolates multi-drug-resistant strains. The overall antimicrobial potency of complexes was enhanced in comparison with the free ligand, against both planktonic and biofilm-embedded pathogenic strains. Complexes exhibit no cytotoxicity on the HCT 8 tumour cells. Thermogravimetric curves (TG, DTG and DTA) evidenced in air processes as water elimination, acetate into carbonate transformation as well as oxidative degradation of the bismacrocyclic ligand. The powder X-ray diffraction data indicate MO (M: Ni, Cu, Zn) as final product.


Complexes Bismacrocycle One-pot condensation Antimicrobial Thermal behaviour 


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2016

Authors and Affiliations

  • Mihaela Badea
    • 1
  • Cristina Bucur
    • 1
    • 2
  • Mariana Carmen Chifiriuc
    • 3
    • 4
  • Coralia Bleotu
    • 5
  • Maria-Nicoleta Grecu
    • 6
  • Veronica Lazar
    • 3
    • 4
  • Dana Marinescu
    • 1
  • Rodica Olar
    • 1
  1. 1.Department of Inorganic Chemistry, Faculty of ChemistryUniversity of BucharestBucharestRomania
  2. 2.Institute for Control of Biological Products and Veterinary MedicinesBucharestRomania
  3. 3.Department of Microbiology, Faculty of BiologyUniversity of BucharestBucharestRomania
  4. 4.Research Institute of the University of BucharestBucharestRomania
  5. 5.Stefan S Nicolau Institute of VirologyBucharestRomania
  6. 6.National Institute for Materials PhysicsBucharest-MagureleRomania

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