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Journal of Thermal Analysis and Calorimetry

, Volume 113, Issue 3, pp 1037–1047 | Cite as

Poly(vinyl pyrrolidone)–poloxamer-188 solid dispersions prepared by hot melt extrusion

Thermal properties and release behavior
  • Emmanouil Fousteris
  • Petroula A. Tarantili
  • Evangelos Karavas
  • Dimitrios Bikiaris
Article

Abstract

Poly(vinyl pyrrolidone) (PVP)/poloxamer-188 blends were used as appropriate carriers for the preparation of solid dispersions by hot melt extrusion using aripiprazole (ARIP) as a poor water-soluble model drug. The physical state of ARIP in solid dispersions and its dissolution characteristics were tested for different drug contents and various PVP-to-poloxamer ratios. From TG analysis it was found that all materials were stable at the tested extrusion temperature conditions (110–120 °C) while amorphous drug dispersions were prepared in all cases, due to the miscibility of the polymer matrix with ARIP drug. Furthermore, hydrogen bonds were identified between ARIP (>N–H) and PVP (>C=O) using FT-IR analysis. Finally, ARIP dissolution rate from SDs was pH dependant and increased as the drug content decreased.

Keywords

Melt mixing Solid dispersions Aripiprazole PVP Poloxamer-188 Dissolution enhancement 

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2013

Authors and Affiliations

  • Emmanouil Fousteris
    • 1
  • Petroula A. Tarantili
    • 1
  • Evangelos Karavas
    • 2
  • Dimitrios Bikiaris
    • 3
  1. 1.Laboratory of Polymer Technology, School of Chemical EngineeringNational Technical University of AthensAthensGreece
  2. 2.Pharmathen S.A., Pharmaceutical IndustryAttikiGreece
  3. 3.Laboratory of Polymer Chemistry and Technology, Department of ChemistryAristotle University of ThessalonikiThessalonikiGreece

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