Journal of Thermal Analysis and Calorimetry

, Volume 105, Issue 2, pp 645–650 | Cite as

Thermal degradation behavior of some ruthenium complexes with fluoroquinolone derivatives as potential antitumor agents

  • Valentina Uivarosi
  • Mihaela Badea
  • Rodica Olar
  • Dana Marinescu
  • Teodor Octavian Nicolescu
  • George Mihai Nitulescu
Article
First Online:

Abstract

Three new complexes with ligands belong to the fluoroquinolone class having the general formula [RuL2Cl2]Cl nH2O ((1) L: norfloxacin (nf), n = 4; (2) L: ciprofloxacin (cp), n = 3; (3) L: enrofloxacin (enro), n = 5) were synthesized and characterized by chemical analysis UV–Vis and IR spectroscopy. In all complexes fluoroquinolone derivative acts as bidentate chelate ligand. The thermal behavior steps were investigated in synthetic air flow. The thermal transformations are complex processes according to TG and DTG curves including dehydration, quinolone derivative degradation, as well as RuCl3 conversion in RuO2.

Keywords

Fluoroquinolone Ruthenium complexes Thermal behavior 
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Notes

Acknowledgements

This study was partially supported by the PNII Grant no. 61-48/2007 of the Romanian Ministry of Education and Research.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2010

Authors and Affiliations

  • Valentina Uivarosi
    • 1
  • Mihaela Badea
    • 2
  • Rodica Olar
    • 2
  • Dana Marinescu
    • 2
  • Teodor Octavian Nicolescu
    • 3
  • George Mihai Nitulescu
    • 4
  1. 1.Department of Inorganic ChemistryCarol Davila University of Medicine and PharmacyBucharestRomania
  2. 2.Faculty of Chemistry, Department of Inorganic ChemistryUniversity of BucharestBucharestRomania
  3. 3.Department of Organic ChemistryCarol Davila University of Medicine and PharmacyBucharestRomania
  4. 4.Department of Pharmaceutical ChemistryCarol Davila University of Medicine and PharmacyBucharestRomania

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