Journal of Thermal Analysis and Calorimetry

, Volume 102, Issue 1, pp 37–42 | Cite as

Heat-treated biodegradable films and foils of collagen hydrolysate crosslinked with dialdehyde starch

  • F. LangmaierEmail author
  • P. Mokrejs
  • M. Mladek


Gels of collagen hydrolysate (H) crosslinked with dialdehyde starch (DAS) are marked by a strong tendency to aging, which means a certain problem during their processing into biodegradable packaging materials. Applying casting technology and drying these materials by heating air-dry films and foils for a limited time (1–4 h) at 105 °C may eliminate the aging problem. Solubility of heat-treated films in an aqueous environment remains preserved, but depending on how long this temperature acts and on the DAS content in the film, time of film disintegration prolongs from 1–1.5 h to 1300 h (≈54 days). It is probably caused by the functional groups initially blocked by sorbed water, which get released to produce hydrogen inter-chain crosslinks. The decrease in glass transition temperature (T g) of such films varies with content of water sorbed in films in an interval of 90.2–189 °C.


Collagen hydrolysate Dialdehyde starch Film curing Film disintegration Thermal treatment 



This work was accomplished in the scope of grant no. 7088352102. The authors wish to express their thanks to the Ministry of Education of the Czech Republic for financial support to this work.


  1. 1.
    Kolomaznik K, Mladek M, Langmaier F, Janacova D, Taylor MM. Experience in industrial practice of enzymatic dechromation of chrome shavings. J Am Leather Chem Assoc. 2000;95:55–63.Google Scholar
  2. 2.
    Langmaier F, Kolomaznik K, Mladek M. Products of enzymatic decomposition of chrome-tanned leather waste. J Soc Leather Technol Chem. 1999;83:187–95.Google Scholar
  3. 3.
    Langmaier F, Mokrejs P, Kolomaznik K, Mladek M. Biodegradable packing materials from hydrolysates of collagen waste proteins. Waste Manage. 2008;28:549–56.CrossRefGoogle Scholar
  4. 4.
    Draye JP, Delaey B, van de Woorde A, van den Bulcke A, Bogdanov B, Schacht E. In vitro release characteristics of bioactive molecules from dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials. 1998;19:99–107.CrossRefGoogle Scholar
  5. 5.
    Langmaier F, Mladek M, Mokrejs P, Kolomaznik K. Biodegradable packing materials based on waste collagen hydrolysate cured with dialdehyde starch. J Therm Anal Calorim. 2008;93:547–52.CrossRefGoogle Scholar
  6. 6.
    Jones BE. Manufacture and properties of two-piece hard capsules. In: Podczeck F, Jones BE, editors. Pharmaceutical capsules. London: Pharmaceutical Press; 2004. p. 79–100.Google Scholar
  7. 7.
    Swarbrick J. Encyclopedia of pharmaceutical technology. 3rd ed. New York: Informa Health Care; 2007.Google Scholar
  8. 8.
    Vassileva E, Calleja FJB, Cagiao ME, Fakirov S. New aspects of thermal treatment effects on gelatin films studied by microhardness. Macromol Chem Phys. 1999;200:405–12.CrossRefGoogle Scholar
  9. 9.
    Kozlov PV, Burdygina GI. The structure and properties of solid gelatin and the principles of their modification. Polymer. 1983;24:651–66.CrossRefGoogle Scholar
  10. 10.
    Langmaier F, Mladek M, Mokrejs P, Kolomaznik K. Hydrogels of collagen hydrolysate cross-linked with dialdehyde starch. J Therm Anal Calorim. 2009. doi: 10.1007/s10973-009-0175-4.
  11. 11.
    Langmaier F, Mokrejs P, Kolomaznik K, Mladek M. Plasticizing collagen hydrolysate with glycerol and low-molecular poly(ethylene glycols). Thermochim Acta. 2008;469:52–8.CrossRefGoogle Scholar
  12. 12.
    Einerson NJ, Stevens KR, Kao WJ. Synthesis and physicochemical analysis of gelatin-based hydrogels for drug carrier matrices. Biomaterials. 2003;24:509–23.CrossRefGoogle Scholar
  13. 13.
    Dixon JW, Massey FJ. Introduction to statistical analysis. 3rd ed. New York: McGraw-Hill; 1969.Google Scholar
  14. 14.
    Stange K. Angewandte statistic, Teil 2: Mehrdimensionale Probleme. Heidelberg: Springer Verlag; 1971.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2009

Authors and Affiliations

  1. 1.Faculty of Technology, Institute of Polymer EngineeringTomas Bata UniversityZlínThe Czech Republic

Personalised recommendations