Application of thermal analysis to the study of lipidic prodrug incorporation into nanocarriers

  • Jennifer Bourgeois
  • Laure-Anne Pierson
  • Julien Nicolas
  • Muriel Lalanne
  • Patrick Couvreur
  • Karine Andrieux
Article

Abstract

Anti HIV molecules as numerous drugs cannot efficiently penetrate into the brain. Prodrug synthesis and encapsulation into pegylated nanocarriers have been proposed as an approach for brain delivery. Pegylated polymeric nanoparticles and liposomes were chosen to incorporate glycerolipidic prodrugs of didanosine. Differential scanning calorimetry experiments were performed on mixtures of prodrugs and lipids or polymer in order to study their interaction. The optimal incorporation ratios were determined for each prodrug and compared for both types of nanocarriers. All these results would be used to prepare optimised formulations of didanosine prodrugs loaded into pegylated nanocarriers for brain drug delivery.

Keywords

Didanosine DSC Glycerolipidic prodrug HIV Incorporation ratio Nanocarriers Polyethyleneglycol 

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2009

Authors and Affiliations

  • Jennifer Bourgeois
    • 1
  • Laure-Anne Pierson
    • 1
  • Julien Nicolas
    • 1
  • Muriel Lalanne
    • 1
  • Patrick Couvreur
    • 1
  • Karine Andrieux
    • 1
  1. 1.Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Faculté de PharmacieUMR CNRS 8612, Université Paris sud 11Chatenay-MalabryFrance

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