Journal of Thermal Analysis and Calorimetry

, Volume 90, Issue 3, pp 903–907 | Cite as

Thermal behaviour of diclofenac, diclofenac sodium and sodium bicarbonate compositions

  • Irene Pasquali
  • R. Bettini
  • F. Giordano


This work aims to investigate the thermal behaviour of diclofenac, diclofenac sodium, and NaHCO3 both as single components and binary mixtures. In particular, the melting point and latent heat of fusion binary diagrams of the diclofenac sodium/diclofenac mixtures at different mole fraction compositions were investigated in order to gain information about the thermal behaviour of their solid mixtures. A good agreement between liquidus curves, calculated by the Schroeder-Van Laar equation from fusion enthalpies and temperatures, and the experimental results was found. For all binary compositions, an endothermic effect at 153°C, probably due to the eutectic fusion, is present.


binary melting point diagram diclofenac diclofenac sodium eutectics 


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  1. 1.
    A. Chiarini, A. Tartarici and A. Fini, Arch. Pharm., 317 (1984) 268.CrossRefGoogle Scholar
  2. 2.
    A. Fini, G. Fazio and I. Rapaport, Drug Exp. Clin. Res., 19 (1993) 81.Google Scholar
  3. 3.
    K. M. O’Connor and O. I. Corrigan, Int. J. Pharm., 226 (2001) 163.CrossRefGoogle Scholar
  4. 4.
    R. Bettini, G. Bertolini, E. Frigo, A. Rossi, I. Casini, I. Pasquali and F. Giordano, J. Therm. Anal. Cal., 77 (2004) 625.CrossRefGoogle Scholar
  5. 5.
    A. K. Galvey, J. Therm. Anal. Cal., 82 (2005) 423.CrossRefGoogle Scholar
  6. 6.
    F. Giordano, A. Rossi, I. Pasquali, R. Bettini, E. Frigo, A Gazzaniga, M. E. Sangalli, V. Mileo and S. Catinella, J. Therm. Anal. Cal., 73 (2003) 509.CrossRefGoogle Scholar
  7. 7.
    J. T. Carstensen, Advanced Pharmaceutical Solids, Marcel Dekker, New York 2001, p. 171.Google Scholar
  8. 8.
    K. Khimeche and A. Dahmani, J. Therm. Anal. Cal., 84 (2006) 47.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2007

Authors and Affiliations

  1. 1.Department of PharmacyUniversity of ParmaParmaItaly

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