Journal of Thermal Analysis and Calorimetry

, Volume 89, Issue 3, pp 709–715 | Cite as

Grinding of drugs with pharmaceutical excipients at cryogenic temperatures

Part II. Cryogenic grinding of indomethacin-polyvinylpyrrolidone mixtures
  • T. P. Shakhtshneider
  • F. Danède
  • F. Capet
  • J. F. Willart
  • M. Descamps
  • L. Paccou
  • E. V. Surov
  • E. V. Boldyreva
  • V. V. Boldyrev


The effect of cryogenic grinding on the indomethacin (IMC) and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry. Cryoground mixtures were shown to form glass solutions. PVP inhibits the crystallization of IMC from the amorphous state: the crystallization temperature of IMC in the mixtures with PVP increases, and the amorphous state is preserved longer on storage. The mixtures were characterized by Raman spectroscopy. Dissolution of the IMC in the cryoground mixtures is higher as compared to the pure form, also after a prolonged storage.


cryogrinding crystallization glass solution glass transition indomethacin polyvinylpyrrolidone 


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Copyright information

© Springer Science+Business Media LLC 2007

Authors and Affiliations

  • T. P. Shakhtshneider
    • 1
    • 2
  • F. Danède
    • 3
  • F. Capet
    • 3
  • J. F. Willart
    • 3
  • M. Descamps
    • 3
  • L. Paccou
    • 3
  • E. V. Surov
    • 2
  • E. V. Boldyreva
    • 1
    • 2
  • V. V. Boldyrev
    • 1
    • 2
  1. 1.Institute of Solid State Chemistry and Mechanochemistry SB RASNovosibirskRussia
  2. 2.Research and Education Centre ‘Molecular Design and Ecologically Safe Technologies’ at Novosibirsk State UniversityNovosibirskRussia
  3. 3.Laboratoire de Dynamique et Structure des Matériaux MoléculairesUMR CNRS 8024Villeneuve d’AscqFrance

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