Journal of Thermal Analysis and Calorimetry

, Volume 89, Issue 3, pp 699–707 | Cite as

Grinding of drugs with pharmaceutical excipients at cryogenic temperatures

Part I. Cryogenic grinding of piroxicam-polyvinylpyrrolidone mixtures
  • T. P. Shakhtshneider
  • F. Danède
  • F. Capet
  • J. F. Willart
  • M. Descamps
  • S. A. Myz
  • E. V. Boldyreva
  • V. V. Boldyrev
Article

Abstract

The effect of cryogenic grinding on the piroxicam and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry (DSC). The crystallization of the amorphous piroxicam obtained during cryogrinding showed two events in a DSC curve (noticeable for pure piroxicam, and much more pronounced for the PVP-piroxicam mixtures). For the same measurement conditions, the intensity ratio of the peaks corresponding to the two events differed for the PVP-piroxicam mixtures of different drug-excipient ratios. The temperatures, at which these events were observed, increased with the increase in the PVP-concentration in the mixture. For the mixtures with a high relative content of PVP (≥60%), crystallization was not observed at all. Only one glass transition was revealed for the mixture containing 80% PVP suggesting that a molecular alloy was formed.

Keywords

cryogrinding crystallization glass transition molecular alloy piroxicam polyvinylpyrrolidone 

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Copyright information

© Springer Science+Business Media LLC 2007

Authors and Affiliations

  • T. P. Shakhtshneider
    • 1
    • 2
  • F. Danède
    • 3
  • F. Capet
    • 3
  • J. F. Willart
    • 3
  • M. Descamps
    • 3
  • S. A. Myz
    • 1
    • 2
  • E. V. Boldyreva
    • 1
    • 2
  • V. V. Boldyrev
    • 1
    • 2
  1. 1.Institute of Solid State Chemistry and Mechanochemistry SB RASNovosibirskRussia
  2. 2.Research and Education Centre ‘Molecular Design and Ecologically Safe Technologies’ at Novosibirsk State UniversityNovosibirskRussia
  3. 3.Laboratoire de Dynamique et Structure des Matériaux MoléculairesUMR CNRS 8024Villeneuve d’AscqFrance

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