Tri-responsive porous silica carrier with gold nanoparticles for chemophotothermal combination therapy

  • Yunyun Chen
  • Yanbao ZhaoEmail author
  • Lei Sun
  • Xueyan Zou
Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications


A multifunctional nanoplatform (pSiO2–Au/HA) combining porous silica (pSiO2) carriers and gold nanoparticles (Au NPs) was synthesized for chemophotothermal synergistic therapy. The pSiO2 carrier has the diameter size of 70 nm and high specific surface area (510.8 m2·g−1). Au NPs as photothermal agents and gatekeepers were linked to pSiO2 carriers by Au–S bonds for redox-responsive drug release and photothermal effect. Hyaluronic acid (HA) molecules were conjugated by the amide bonds on the surface of porous silica (pSiO2) to seal the drug-loaded pores and endow it pH-and enzyme-responsive property. The results demonstrated that pSiO2–Au/HA carriers displayed good pH/redox/enzyme-responsive release behavior and photothermal effect, which may be a good promising targeted delivery systems for chemophotothermal therapy.


  • Porous silica (pSiO2) carriers were successfully prepared for drug release.

  • Hyaluronic acid (HA) and gold nanoparticles (Au NPs) are used to seal the loaded drug.

  • pSiO2-Au/HA carriers display pH/redox/enzyme-responsive release behavior.

  • pSiO2-Au/HA carriers exhibit good aqueous and photostability.


Porous silica Nanocarriers Controlling release Photothermal effect 



Financial support of this work from National Natural Science Foundation of China (21271062) is gratefully acknowledged.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Engineering Research Center for NanomaterialsHenan UniversityKaifengChina

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