Comparison and evaluation of in vitro degradation behaviors of organosilicone-modified gelatin hybrids
Degradation behavior is one of the most important characteristics of biomedical materials for their applications. Herein, we systematically investigate the in vitro degradation behaviors of γ-glycidoxypropyltrimethoxysilane (GT) and/or epoxy-terminated polydimethylsiloxane oligomer (ES)-modified gelatin hybrid materials in physiological conditions. Their microscopic appearance, chemical composition, thermal performance, and mechanical properties at different degradation periods were thoroughly characterized by a series of measurements. It was found that the degradation behavior of silica–gelatin hybrids could be modulated by controlling the proportion of GT to ES oligomers. In particular, ES/GT-G hybrid as a result of combination of ES and GT, exhibited a faster degradation rate than that of GT-G hybrid when using merely GT, and showed a more homogeneous degradation behavior during the degradation process. Additionally, these silica–gelatin hybrids showed low cytotoxicity to human renal epithelial cells, and the cell viability was all above 83%. This work is helpful for a further insight into the in vivo degradation of silica–gelatin hybrid scaffolds, which are promising in biomedical applications.
In vitro degradation behaviors of silica–gelatin hybrids were tested in physiological conditions.
Degradation behaviors of silica–gelatin hybrids could be modulated by the proportion of GT to ES oligomers.
ES/GT-G hybrid showed a faster and more homogeneous degradation performance.
The prepared silica–gelatin hybrids exhibited cytocompatibility in vitro.
KeywordsSilica–gelatin hybrid Organosilicone oligomer Degradation Cytotoxicity Biomaterial
This work was supported by the National Natural Science Foundation of China (No. 21376153) and Suzhou International Science and Technology Cooperative Project (SH201108). The authors would thank Wang Zhonghui (College of Light Industry, Textile, and Food Engineering, Sichuan University) for her great help in SEM observation.
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Conflict of interest
The authors declare that they have no conflict of interest.
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